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Val279Phe variant of Lp-PLA2 is a risk factor for a subpopulation of Indonesia patients with acute myocardial infarction
Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), a member of the phospholipase A(2) superfamily, is an enzyme that hydrolyses phospholipids, is found in blood circulation as a sign of inflammation, and takes a role in atherogenesis. There is an epidemiologic relation between increased Lp-PLA(2...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chongqing Medical University
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147166/ https://www.ncbi.nlm.nih.gov/pubmed/30258899 http://dx.doi.org/10.1016/j.gendis.2016.08.002 |
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author | Cahyaningtias, Miryanti Rohman, Mohammad Saifur Widodo Wahjono Adi, Andi Yuda, Rina Indrayana, Yanna Putri, Jayarani Fatimah Rusdianto Lukitasari, Mifetika Hendrawan, Dadang |
author_facet | Cahyaningtias, Miryanti Rohman, Mohammad Saifur Widodo Wahjono Adi, Andi Yuda, Rina Indrayana, Yanna Putri, Jayarani Fatimah Rusdianto Lukitasari, Mifetika Hendrawan, Dadang |
author_sort | Cahyaningtias, Miryanti |
collection | PubMed |
description | Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), a member of the phospholipase A(2) superfamily, is an enzyme that hydrolyses phospholipids, is found in blood circulation as a sign of inflammation, and takes a role in atherogenesis. There is an epidemiologic relation between increased Lp-PLA(2) levels and coronary heart disease. Lp-PLA(2) is an enzyme that is produced by macrophages and takes a role as an independent predictor of a coronary event. A genetic variant of Val279Phe on the Lp-PLA(2) gene has been reported with various results in Japan, China, Korea, and Caucasian populations. This study aims to analyse the influence of the Val279Phe genetic variant on acute myocardial infarction (AMI) at Saiful Anwar Hospital, Indonesia. This study was conducted on 151 patients (111 AMI patients and 40 non-AMI patients). The genetic variant of Val279Phe was identified through a genotyping method. There were no significant differences in age, total cholesterol level, LDL-C (low-density lipoprotein cholesterol) level, and family history data between AMI and non-AMI patients. However, AMI patients had low HDL-C (high-density lipoprotein cholesterol), triglyceride levels, dyslipidaemia, and hypertension risk factors compared to non-AMI patients. The frequency of the GG genotype (279Val) was dominant in both AMI and non-AMI groups. Further analysis suggested that the GG genotype has a 2.9 times greater risk of AMI compared to the GT/TT genotype (279Phe). This study concluded that the Val279Phe genetic variant undoubtedly influenced AMI risk, which is a warrant for further development of early detection and improving strategy to prevent AMI in patients. |
format | Online Article Text |
id | pubmed-6147166 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Chongqing Medical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-61471662018-09-26 Val279Phe variant of Lp-PLA2 is a risk factor for a subpopulation of Indonesia patients with acute myocardial infarction Cahyaningtias, Miryanti Rohman, Mohammad Saifur Widodo Wahjono Adi, Andi Yuda, Rina Indrayana, Yanna Putri, Jayarani Fatimah Rusdianto Lukitasari, Mifetika Hendrawan, Dadang Genes Dis Article Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), a member of the phospholipase A(2) superfamily, is an enzyme that hydrolyses phospholipids, is found in blood circulation as a sign of inflammation, and takes a role in atherogenesis. There is an epidemiologic relation between increased Lp-PLA(2) levels and coronary heart disease. Lp-PLA(2) is an enzyme that is produced by macrophages and takes a role as an independent predictor of a coronary event. A genetic variant of Val279Phe on the Lp-PLA(2) gene has been reported with various results in Japan, China, Korea, and Caucasian populations. This study aims to analyse the influence of the Val279Phe genetic variant on acute myocardial infarction (AMI) at Saiful Anwar Hospital, Indonesia. This study was conducted on 151 patients (111 AMI patients and 40 non-AMI patients). The genetic variant of Val279Phe was identified through a genotyping method. There were no significant differences in age, total cholesterol level, LDL-C (low-density lipoprotein cholesterol) level, and family history data between AMI and non-AMI patients. However, AMI patients had low HDL-C (high-density lipoprotein cholesterol), triglyceride levels, dyslipidaemia, and hypertension risk factors compared to non-AMI patients. The frequency of the GG genotype (279Val) was dominant in both AMI and non-AMI groups. Further analysis suggested that the GG genotype has a 2.9 times greater risk of AMI compared to the GT/TT genotype (279Phe). This study concluded that the Val279Phe genetic variant undoubtedly influenced AMI risk, which is a warrant for further development of early detection and improving strategy to prevent AMI in patients. Chongqing Medical University 2016-09-17 /pmc/articles/PMC6147166/ /pubmed/30258899 http://dx.doi.org/10.1016/j.gendis.2016.08.002 Text en Copyright © 2016, Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Cahyaningtias, Miryanti Rohman, Mohammad Saifur Widodo Wahjono Adi, Andi Yuda, Rina Indrayana, Yanna Putri, Jayarani Fatimah Rusdianto Lukitasari, Mifetika Hendrawan, Dadang Val279Phe variant of Lp-PLA2 is a risk factor for a subpopulation of Indonesia patients with acute myocardial infarction |
title | Val279Phe variant of Lp-PLA2 is a risk factor for a subpopulation of Indonesia patients with acute myocardial infarction |
title_full | Val279Phe variant of Lp-PLA2 is a risk factor for a subpopulation of Indonesia patients with acute myocardial infarction |
title_fullStr | Val279Phe variant of Lp-PLA2 is a risk factor for a subpopulation of Indonesia patients with acute myocardial infarction |
title_full_unstemmed | Val279Phe variant of Lp-PLA2 is a risk factor for a subpopulation of Indonesia patients with acute myocardial infarction |
title_short | Val279Phe variant of Lp-PLA2 is a risk factor for a subpopulation of Indonesia patients with acute myocardial infarction |
title_sort | val279phe variant of lp-pla2 is a risk factor for a subpopulation of indonesia patients with acute myocardial infarction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147166/ https://www.ncbi.nlm.nih.gov/pubmed/30258899 http://dx.doi.org/10.1016/j.gendis.2016.08.002 |
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