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Deciphering the role of microRNA 21 in cancer stem cells (CSCs)

Irrespective of positive developments of cancer treatment, the mortality due to various cancers remains high and the mechanisms of cancer initiation and the development also remains mysterious. As we know that microRNAs are considered to be a short noncoding RNA molecules consisting of 21–25 nucleot...

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Autores principales: Sekar, Durairaj, Krishnan, Ramalingam, Panagal, Mani, Sivakumar, Pethanen, Gopinath, Vincent, Basam, Venugopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147178/
https://www.ncbi.nlm.nih.gov/pubmed/30258897
http://dx.doi.org/10.1016/j.gendis.2016.05.002
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author Sekar, Durairaj
Krishnan, Ramalingam
Panagal, Mani
Sivakumar, Pethanen
Gopinath, Vincent
Basam, Venugopal
author_facet Sekar, Durairaj
Krishnan, Ramalingam
Panagal, Mani
Sivakumar, Pethanen
Gopinath, Vincent
Basam, Venugopal
author_sort Sekar, Durairaj
collection PubMed
description Irrespective of positive developments of cancer treatment, the mortality due to various cancers remains high and the mechanisms of cancer initiation and the development also remains mysterious. As we know that microRNAs are considered to be a short noncoding RNA molecules consisting of 21–25 nucleotides (nt) in length and they silence their target genes by inhibiting mRNA translation or degrading the mRNA molecules by binding to their 3′-untranslated (UTR) region and play a very important role in cancer biology. Recent evidences indicate that miR-21 is over expressed in cancer stem cells and plays a vital role in cell proliferation, apoptosis, and invasion. Even though an increased expression level of miR-21 has been observed in cancer stem cells, studies related to the role of miR-21 in cancer stem cells are limited. The main aim of this mini review is to explain the potency of miR-21 in various cancer stem cells (CSCs) and as a new target for therapeutic interventions of cancer progression.
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spelling pubmed-61471782018-09-26 Deciphering the role of microRNA 21 in cancer stem cells (CSCs) Sekar, Durairaj Krishnan, Ramalingam Panagal, Mani Sivakumar, Pethanen Gopinath, Vincent Basam, Venugopal Genes Dis Article Irrespective of positive developments of cancer treatment, the mortality due to various cancers remains high and the mechanisms of cancer initiation and the development also remains mysterious. As we know that microRNAs are considered to be a short noncoding RNA molecules consisting of 21–25 nucleotides (nt) in length and they silence their target genes by inhibiting mRNA translation or degrading the mRNA molecules by binding to their 3′-untranslated (UTR) region and play a very important role in cancer biology. Recent evidences indicate that miR-21 is over expressed in cancer stem cells and plays a vital role in cell proliferation, apoptosis, and invasion. Even though an increased expression level of miR-21 has been observed in cancer stem cells, studies related to the role of miR-21 in cancer stem cells are limited. The main aim of this mini review is to explain the potency of miR-21 in various cancer stem cells (CSCs) and as a new target for therapeutic interventions of cancer progression. Chongqing Medical University 2016-06-24 /pmc/articles/PMC6147178/ /pubmed/30258897 http://dx.doi.org/10.1016/j.gendis.2016.05.002 Text en Copyright © 2016, Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Sekar, Durairaj
Krishnan, Ramalingam
Panagal, Mani
Sivakumar, Pethanen
Gopinath, Vincent
Basam, Venugopal
Deciphering the role of microRNA 21 in cancer stem cells (CSCs)
title Deciphering the role of microRNA 21 in cancer stem cells (CSCs)
title_full Deciphering the role of microRNA 21 in cancer stem cells (CSCs)
title_fullStr Deciphering the role of microRNA 21 in cancer stem cells (CSCs)
title_full_unstemmed Deciphering the role of microRNA 21 in cancer stem cells (CSCs)
title_short Deciphering the role of microRNA 21 in cancer stem cells (CSCs)
title_sort deciphering the role of microrna 21 in cancer stem cells (cscs)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147178/
https://www.ncbi.nlm.nih.gov/pubmed/30258897
http://dx.doi.org/10.1016/j.gendis.2016.05.002
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