MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients

This study was performed for investigation the relationship between variants of MTP gene polymorphism and the development of NAFLD in patients with and without MS. The study was included 174 NAFLD patients (106 with MS and 68 without MS), and 141 healthy control subjects. The 493 G/T polymorphism of...

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Autores principales: Gouda, Weaam, Ashour, Esmat, Shaker, Yehia, Ezzat, Wafaa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147179/
https://www.ncbi.nlm.nih.gov/pubmed/30258926
http://dx.doi.org/10.1016/j.gendis.2017.09.002
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author Gouda, Weaam
Ashour, Esmat
Shaker, Yehia
Ezzat, Wafaa
author_facet Gouda, Weaam
Ashour, Esmat
Shaker, Yehia
Ezzat, Wafaa
author_sort Gouda, Weaam
collection PubMed
description This study was performed for investigation the relationship between variants of MTP gene polymorphism and the development of NAFLD in patients with and without MS. The study was included 174 NAFLD patients (106 with MS and 68 without MS), and 141 healthy control subjects. The 493 G/T polymorphism of MTP gene was evaluated by PCR-RFLP method. The frequency of MTP TT genotype and T allele were significantly higher in NAFLD patients when compared to healthy controls. Moreover, a significant association in MTP gene polymorphism was observed in NAFLD patients with MS compared to NAFLD patients without MS and controls. Our study suggested that MTP 493 G/T gene polymorphism may act as susceptibility biomarker for NAFLD and MS.
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spelling pubmed-61471792018-09-26 MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients Gouda, Weaam Ashour, Esmat Shaker, Yehia Ezzat, Wafaa Genes Dis Article This study was performed for investigation the relationship between variants of MTP gene polymorphism and the development of NAFLD in patients with and without MS. The study was included 174 NAFLD patients (106 with MS and 68 without MS), and 141 healthy control subjects. The 493 G/T polymorphism of MTP gene was evaluated by PCR-RFLP method. The frequency of MTP TT genotype and T allele were significantly higher in NAFLD patients when compared to healthy controls. Moreover, a significant association in MTP gene polymorphism was observed in NAFLD patients with MS compared to NAFLD patients without MS and controls. Our study suggested that MTP 493 G/T gene polymorphism may act as susceptibility biomarker for NAFLD and MS. Chongqing Medical University 2017-10-16 /pmc/articles/PMC6147179/ /pubmed/30258926 http://dx.doi.org/10.1016/j.gendis.2017.09.002 Text en © 2017 Chongqing Medical University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Gouda, Weaam
Ashour, Esmat
Shaker, Yehia
Ezzat, Wafaa
MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients
title MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients
title_full MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients
title_fullStr MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients
title_full_unstemmed MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients
title_short MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients
title_sort mtp genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147179/
https://www.ncbi.nlm.nih.gov/pubmed/30258926
http://dx.doi.org/10.1016/j.gendis.2017.09.002
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