Synthesis and Characterisation of Macrocyclic Diamino Chiral Crown Ethers

A benign and efficient synthesis of chiral macrocyclic ‘aza-crown’ ethers of varying ring size is reported. The synthesis involves a Schiff base condensation of ether linked dialdehydes of varying chain length and (1R,2R)-(–)-1,2-diaminocyclohexane under mild conditions to yield the macrocycles, whi...

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Detalles Bibliográficos
Autores principales: Correa, Waldo H., Scott, Janet L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147343/
https://www.ncbi.nlm.nih.gov/pubmed/18007450
http://dx.doi.org/10.3390/90600513
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author Correa, Waldo H.
Scott, Janet L.
author_facet Correa, Waldo H.
Scott, Janet L.
author_sort Correa, Waldo H.
collection PubMed
description A benign and efficient synthesis of chiral macrocyclic ‘aza-crown’ ethers of varying ring size is reported. The synthesis involves a Schiff base condensation of ether linked dialdehydes of varying chain length and (1R,2R)-(–)-1,2-diaminocyclohexane under mild conditions to yield the macrocycles, which are subsequently reduced to yield the diamino analogues.
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spelling pubmed-61473432018-11-19 Synthesis and Characterisation of Macrocyclic Diamino Chiral Crown Ethers Correa, Waldo H. Scott, Janet L. Molecules Article A benign and efficient synthesis of chiral macrocyclic ‘aza-crown’ ethers of varying ring size is reported. The synthesis involves a Schiff base condensation of ether linked dialdehydes of varying chain length and (1R,2R)-(–)-1,2-diaminocyclohexane under mild conditions to yield the macrocycles, which are subsequently reduced to yield the diamino analogues. MDPI 2004-05-31 /pmc/articles/PMC6147343/ /pubmed/18007450 http://dx.doi.org/10.3390/90600513 Text en © 2004 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Correa, Waldo H.
Scott, Janet L.
Synthesis and Characterisation of Macrocyclic Diamino Chiral Crown Ethers
title Synthesis and Characterisation of Macrocyclic Diamino Chiral Crown Ethers
title_full Synthesis and Characterisation of Macrocyclic Diamino Chiral Crown Ethers
title_fullStr Synthesis and Characterisation of Macrocyclic Diamino Chiral Crown Ethers
title_full_unstemmed Synthesis and Characterisation of Macrocyclic Diamino Chiral Crown Ethers
title_short Synthesis and Characterisation of Macrocyclic Diamino Chiral Crown Ethers
title_sort synthesis and characterisation of macrocyclic diamino chiral crown ethers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147343/
https://www.ncbi.nlm.nih.gov/pubmed/18007450
http://dx.doi.org/10.3390/90600513
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