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Clinical, hemato-biochemical alterations and oxidant–antioxidant biomarkers in Babesia-infected calves
Babesia is one of the main causes of anemia in cattle, a lot of elucidations have been suggested to explain its pathogenesis. This study was designed to investigate clinical, hemato-biochemical and oxidant/antioxidant status and its relation with the resultant anemia in Babesia-infected calves. Seve...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculty of Veterinary Medicine, Cairo University
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147375/ https://www.ncbi.nlm.nih.gov/pubmed/30255034 http://dx.doi.org/10.1016/j.ijvsm.2016.10.003 |
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author | Salem, Noha Y. Yehia, Shimaa G. Farag, Heba S. Elkhiat, Mohammed Awny |
author_facet | Salem, Noha Y. Yehia, Shimaa G. Farag, Heba S. Elkhiat, Mohammed Awny |
author_sort | Salem, Noha Y. |
collection | PubMed |
description | Babesia is one of the main causes of anemia in cattle, a lot of elucidations have been suggested to explain its pathogenesis. This study was designed to investigate clinical, hemato-biochemical and oxidant/antioxidant status and its relation with the resultant anemia in Babesia-infected calves. Seventeen (17) native breed calves were involved in this study, clinical signs and microscopic findings were recorded, also blood samples were taken to investigate hematologic changes, serum biochemical variations and oxidative stress biomarkers. The most commonly observed clinical signs were fever, emaciation, depression, icterus and hemoglobinuria. Significant reduction in PCV, HB, RBCs, MCHC, Total protein, and albumin along with significant increase in MCV, WBCs, monocytes and BUN were the most consistent hemato-biochemical changes. Oxidant/antioxidant and trace mineral assessment showed significant reduction in Superoxide dismutase “SOD”, Glutathione peroxidase “GPx”, Zn, Cu along with significant increase in malondialdehyde (MDA) activities. In the current investigation, oxidant/antioxidant imbalance along with the synchronized alterations in antioxidant trace minerals was detected in Babesia-infected calves. These findings support notion that Babesia infection associated with oxidative stress and this process may be linked to the resultant anemia. |
format | Online Article Text |
id | pubmed-6147375 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Faculty of Veterinary Medicine, Cairo University |
record_format | MEDLINE/PubMed |
spelling | pubmed-61473752018-09-25 Clinical, hemato-biochemical alterations and oxidant–antioxidant biomarkers in Babesia-infected calves Salem, Noha Y. Yehia, Shimaa G. Farag, Heba S. Elkhiat, Mohammed Awny Int J Vet Sci Med Article Babesia is one of the main causes of anemia in cattle, a lot of elucidations have been suggested to explain its pathogenesis. This study was designed to investigate clinical, hemato-biochemical and oxidant/antioxidant status and its relation with the resultant anemia in Babesia-infected calves. Seventeen (17) native breed calves were involved in this study, clinical signs and microscopic findings were recorded, also blood samples were taken to investigate hematologic changes, serum biochemical variations and oxidative stress biomarkers. The most commonly observed clinical signs were fever, emaciation, depression, icterus and hemoglobinuria. Significant reduction in PCV, HB, RBCs, MCHC, Total protein, and albumin along with significant increase in MCV, WBCs, monocytes and BUN were the most consistent hemato-biochemical changes. Oxidant/antioxidant and trace mineral assessment showed significant reduction in Superoxide dismutase “SOD”, Glutathione peroxidase “GPx”, Zn, Cu along with significant increase in malondialdehyde (MDA) activities. In the current investigation, oxidant/antioxidant imbalance along with the synchronized alterations in antioxidant trace minerals was detected in Babesia-infected calves. These findings support notion that Babesia infection associated with oxidative stress and this process may be linked to the resultant anemia. Faculty of Veterinary Medicine, Cairo University 2016-11-30 /pmc/articles/PMC6147375/ /pubmed/30255034 http://dx.doi.org/10.1016/j.ijvsm.2016.10.003 Text en © 2016 Faculty of Veterinary Medicine, Cairo University. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Salem, Noha Y. Yehia, Shimaa G. Farag, Heba S. Elkhiat, Mohammed Awny Clinical, hemato-biochemical alterations and oxidant–antioxidant biomarkers in Babesia-infected calves |
title | Clinical, hemato-biochemical alterations and oxidant–antioxidant biomarkers in Babesia-infected calves |
title_full | Clinical, hemato-biochemical alterations and oxidant–antioxidant biomarkers in Babesia-infected calves |
title_fullStr | Clinical, hemato-biochemical alterations and oxidant–antioxidant biomarkers in Babesia-infected calves |
title_full_unstemmed | Clinical, hemato-biochemical alterations and oxidant–antioxidant biomarkers in Babesia-infected calves |
title_short | Clinical, hemato-biochemical alterations and oxidant–antioxidant biomarkers in Babesia-infected calves |
title_sort | clinical, hemato-biochemical alterations and oxidant–antioxidant biomarkers in babesia-infected calves |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147375/ https://www.ncbi.nlm.nih.gov/pubmed/30255034 http://dx.doi.org/10.1016/j.ijvsm.2016.10.003 |
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