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Low-volume goat milk transmission of classical scrapie to lambs and goat kids
The risk of classical scrapie transmission in small ruminants is highest during the neonatal period with the placenta recognized as a significant source of infection. Milk has also been identified as a source of scrapie with sheep-to-sheep transmission occurring after neonatal consumption of as litt...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147516/ https://www.ncbi.nlm.nih.gov/pubmed/30235307 http://dx.doi.org/10.1371/journal.pone.0204281 |
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author | Madsen-Bouterse, Sally A. Highland, Margaret A. Dassanayake, Rohana P. Zhuang, Dongyue Schneider, David A. |
author_facet | Madsen-Bouterse, Sally A. Highland, Margaret A. Dassanayake, Rohana P. Zhuang, Dongyue Schneider, David A. |
author_sort | Madsen-Bouterse, Sally A. |
collection | PubMed |
description | The risk of classical scrapie transmission in small ruminants is highest during the neonatal period with the placenta recognized as a significant source of infection. Milk has also been identified as a source of scrapie with sheep-to-sheep transmission occurring after neonatal consumption of as little as 1–2 liters of milk; concurrent mastitis due to small ruminant lentivirus (SRLV) infection may be associated with increased scrapie transmission via milk in sheep. In contrast, goat-to-sheep transmission has been documented only after prolonged consumption of >30 liters of milk. The goal of the current study was to assess transmission of scrapie to goat kids and lambs following low volume, short duration consumption of milk from infected goats. Milk from two does (female goats) with pre-clinical scrapie was fed to four goat kids (≤4.5 L each) and four lambs (~3.7 L each) beginning ~24 hours after birth. Scrapie transmission was detected in three sheep as early as 18 months post inoculation; transmission was also detected in two goats but not until postmortem analyses at 33 months post inoculation. Each milk donor goat also had naturally-acquired infection with SRLV. Different degrees of lymphohistiocytic inflammation and PrP(Sc) accumulation were observed in mammary gland tissues of the donors, which appeared to associate with transmission of scrapie via milk. Thus, similar to the risks of milk transmission of scrapie from sheep, even limited exposure to milk from goats can pose significant risk for scrapie transmission to both goat kids and lambs. |
format | Online Article Text |
id | pubmed-6147516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-61475162018-10-08 Low-volume goat milk transmission of classical scrapie to lambs and goat kids Madsen-Bouterse, Sally A. Highland, Margaret A. Dassanayake, Rohana P. Zhuang, Dongyue Schneider, David A. PLoS One Research Article The risk of classical scrapie transmission in small ruminants is highest during the neonatal period with the placenta recognized as a significant source of infection. Milk has also been identified as a source of scrapie with sheep-to-sheep transmission occurring after neonatal consumption of as little as 1–2 liters of milk; concurrent mastitis due to small ruminant lentivirus (SRLV) infection may be associated with increased scrapie transmission via milk in sheep. In contrast, goat-to-sheep transmission has been documented only after prolonged consumption of >30 liters of milk. The goal of the current study was to assess transmission of scrapie to goat kids and lambs following low volume, short duration consumption of milk from infected goats. Milk from two does (female goats) with pre-clinical scrapie was fed to four goat kids (≤4.5 L each) and four lambs (~3.7 L each) beginning ~24 hours after birth. Scrapie transmission was detected in three sheep as early as 18 months post inoculation; transmission was also detected in two goats but not until postmortem analyses at 33 months post inoculation. Each milk donor goat also had naturally-acquired infection with SRLV. Different degrees of lymphohistiocytic inflammation and PrP(Sc) accumulation were observed in mammary gland tissues of the donors, which appeared to associate with transmission of scrapie via milk. Thus, similar to the risks of milk transmission of scrapie from sheep, even limited exposure to milk from goats can pose significant risk for scrapie transmission to both goat kids and lambs. Public Library of Science 2018-09-20 /pmc/articles/PMC6147516/ /pubmed/30235307 http://dx.doi.org/10.1371/journal.pone.0204281 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication. |
spellingShingle | Research Article Madsen-Bouterse, Sally A. Highland, Margaret A. Dassanayake, Rohana P. Zhuang, Dongyue Schneider, David A. Low-volume goat milk transmission of classical scrapie to lambs and goat kids |
title | Low-volume goat milk transmission of classical scrapie to lambs and goat kids |
title_full | Low-volume goat milk transmission of classical scrapie to lambs and goat kids |
title_fullStr | Low-volume goat milk transmission of classical scrapie to lambs and goat kids |
title_full_unstemmed | Low-volume goat milk transmission of classical scrapie to lambs and goat kids |
title_short | Low-volume goat milk transmission of classical scrapie to lambs and goat kids |
title_sort | low-volume goat milk transmission of classical scrapie to lambs and goat kids |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147516/ https://www.ncbi.nlm.nih.gov/pubmed/30235307 http://dx.doi.org/10.1371/journal.pone.0204281 |
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