Synthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidines

A series of 22 novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidine derivatives were synthesized and evaluated for in vitro antibacterial activity against S. aureus and methicillin resistant S. aureus (MRSA), E. coli, E. faecalis and for antifungal activity against C. albicans. Compo...

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Detalles Bibliográficos
Autores principales: Göker, Hakan, Alp, Mehmet, Yıldız, Sulhiye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147528/
https://www.ncbi.nlm.nih.gov/pubmed/18007533
http://dx.doi.org/10.3390/10111377
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author Göker, Hakan
Alp, Mehmet
Yıldız, Sulhiye
author_facet Göker, Hakan
Alp, Mehmet
Yıldız, Sulhiye
author_sort Göker, Hakan
collection PubMed
description A series of 22 novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidine derivatives were synthesized and evaluated for in vitro antibacterial activity against S. aureus and methicillin resistant S. aureus (MRSA), E. coli, E. faecalis and for antifungal activity against C. albicans. Compound 59 [1-(2,4-dichlorobenzyl)-N-(2-diethylaminoethyl)-1H-benzimidazole-5-carboxamidine], with a 3,4-dichlorophenyl group at the C-2 position, displayed the greatest activity (MIC = 3.12 μg/mL against both some bacteria and the fungus C. albicans).
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spelling pubmed-61475282018-11-19 Synthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidines Göker, Hakan Alp, Mehmet Yıldız, Sulhiye Molecules Article A series of 22 novel 1,2-disubstituted-1H-benzimidazole-N-alkylated-5-carboxamidine derivatives were synthesized and evaluated for in vitro antibacterial activity against S. aureus and methicillin resistant S. aureus (MRSA), E. coli, E. faecalis and for antifungal activity against C. albicans. Compound 59 [1-(2,4-dichlorobenzyl)-N-(2-diethylaminoethyl)-1H-benzimidazole-5-carboxamidine], with a 3,4-dichlorophenyl group at the C-2 position, displayed the greatest activity (MIC = 3.12 μg/mL against both some bacteria and the fungus C. albicans). MDPI 2005-11-30 /pmc/articles/PMC6147528/ /pubmed/18007533 http://dx.doi.org/10.3390/10111377 Text en © 2005 by MDPI (http:www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Göker, Hakan
Alp, Mehmet
Yıldız, Sulhiye
Synthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidines
title Synthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidines
title_full Synthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidines
title_fullStr Synthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidines
title_full_unstemmed Synthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidines
title_short Synthesis and Potent Antimicrobial Activity of Some Novel N-(Alkyl)-2-Phenyl-1H-Benzimidazole-5-Carboxamidines
title_sort synthesis and potent antimicrobial activity of some novel n-(alkyl)-2-phenyl-1h-benzimidazole-5-carboxamidines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147528/
https://www.ncbi.nlm.nih.gov/pubmed/18007533
http://dx.doi.org/10.3390/10111377
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AT yıldızsulhiye synthesisandpotentantimicrobialactivityofsomenovelnalkyl2phenyl1hbenzimidazole5carboxamidines

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