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Bioadhesive Properties of Gantrez Nanoparticles

Bioadhesive nanoparticles have been proposed as carriers for the oral delivery of poorly available drugs and facilitate the use of this route. This work summarises some experiments describing the bioadhesive potential of Gantrez nanoparticles fluorescently labeled with rhodamine B isothiocyanate. Th...

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Autores principales: Irache, Juan M., Huici, María, Konecny, Monica, Espuelas, Socorro, Campanero, Miguel Angel, Arbos, Pau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147552/
https://www.ncbi.nlm.nih.gov/pubmed/18007282
http://dx.doi.org/10.3390/10010126
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author Irache, Juan M.
Huici, María
Konecny, Monica
Espuelas, Socorro
Campanero, Miguel Angel
Arbos, Pau
author_facet Irache, Juan M.
Huici, María
Konecny, Monica
Espuelas, Socorro
Campanero, Miguel Angel
Arbos, Pau
author_sort Irache, Juan M.
collection PubMed
description Bioadhesive nanoparticles have been proposed as carriers for the oral delivery of poorly available drugs and facilitate the use of this route. This work summarises some experiments describing the bioadhesive potential of Gantrez nanoparticles fluorescently labeled with rhodamine B isothiocyanate. The adhesive potential of Gantrez was found to be stronger when folded as nanoparticles than in the solubilised form. Conventional nanoparticles displayed a tropism for the upper areas of the gastrointestinal tract, with a maximum of adhesion 30 min post-administration and a decrease in the adhered fraction along the time depending on the given dose. The cross-linkage of nanoparticles with increasing amounts of 1,3-diaminopropane stabilised the resulting carriers and prolonged their half-life in an aqueous environment; although, the adhesive capacity of nanoparticles, the intensity and the relative duration of the adhesive interactions within the gut as a function of the cross-linking degree. Finally, nanoparticles were coated with either gelatin or albumin. In the first case, the presence of gelatin dramatically decreased the initial capacity of these carriers to interact with the gut mucosa and the intensity of these phenomenons. In the latter, bovine serum albumin coated nanoparticles (BSA-NP) showed an important tropism for the stomach mucosa without further significant distribution to other parts of the gut mucosa.
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spelling pubmed-61475522018-11-19 Bioadhesive Properties of Gantrez Nanoparticles Irache, Juan M. Huici, María Konecny, Monica Espuelas, Socorro Campanero, Miguel Angel Arbos, Pau Molecules Article Bioadhesive nanoparticles have been proposed as carriers for the oral delivery of poorly available drugs and facilitate the use of this route. This work summarises some experiments describing the bioadhesive potential of Gantrez nanoparticles fluorescently labeled with rhodamine B isothiocyanate. The adhesive potential of Gantrez was found to be stronger when folded as nanoparticles than in the solubilised form. Conventional nanoparticles displayed a tropism for the upper areas of the gastrointestinal tract, with a maximum of adhesion 30 min post-administration and a decrease in the adhered fraction along the time depending on the given dose. The cross-linkage of nanoparticles with increasing amounts of 1,3-diaminopropane stabilised the resulting carriers and prolonged their half-life in an aqueous environment; although, the adhesive capacity of nanoparticles, the intensity and the relative duration of the adhesive interactions within the gut as a function of the cross-linking degree. Finally, nanoparticles were coated with either gelatin or albumin. In the first case, the presence of gelatin dramatically decreased the initial capacity of these carriers to interact with the gut mucosa and the intensity of these phenomenons. In the latter, bovine serum albumin coated nanoparticles (BSA-NP) showed an important tropism for the stomach mucosa without further significant distribution to other parts of the gut mucosa. MDPI 2005-01-31 /pmc/articles/PMC6147552/ /pubmed/18007282 http://dx.doi.org/10.3390/10010126 Text en © 2005 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Irache, Juan M.
Huici, María
Konecny, Monica
Espuelas, Socorro
Campanero, Miguel Angel
Arbos, Pau
Bioadhesive Properties of Gantrez Nanoparticles
title Bioadhesive Properties of Gantrez Nanoparticles
title_full Bioadhesive Properties of Gantrez Nanoparticles
title_fullStr Bioadhesive Properties of Gantrez Nanoparticles
title_full_unstemmed Bioadhesive Properties of Gantrez Nanoparticles
title_short Bioadhesive Properties of Gantrez Nanoparticles
title_sort bioadhesive properties of gantrez nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147552/
https://www.ncbi.nlm.nih.gov/pubmed/18007282
http://dx.doi.org/10.3390/10010126
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