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Polymeric Particulates to Improve Oral Bioavailability of Peptide Drugs

Oral administration remains the most convenient way of delivering drugs. Recent advances in biotechnology have produced highly potent new molecules such as peptides, proteins and nucleic acids. Due to their sensitivity to chemical and enzymatic hydrolysis as well as a poor cellular uptake, their ora...

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Detalles Bibliográficos
Autores principales: Delie, Florence, Blanco-Príeto, María José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147556/
https://www.ncbi.nlm.nih.gov/pubmed/18007277
http://dx.doi.org/10.3390/10010065
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author Delie, Florence
Blanco-Príeto, María José
author_facet Delie, Florence
Blanco-Príeto, María José
author_sort Delie, Florence
collection PubMed
description Oral administration remains the most convenient way of delivering drugs. Recent advances in biotechnology have produced highly potent new molecules such as peptides, proteins and nucleic acids. Due to their sensitivity to chemical and enzymatic hydrolysis as well as a poor cellular uptake, their oral bioavailability remains very low. Despite sophisticated new delivery systems, the development of a satisfactory oral formulation remains a challenge. Among the possible strategies to improve the absorption of drugs, micro- and nanoparticles represent an exciting approach to enhance the uptake and transport of orally administered molecules. Increasing attention has been paid to their potential use as carriers for peptide drugs for oral administration. This article reviews the most common manufacturing methods for polymeric particles and the physiology of particle absorption from the gastrointestinal (GI) tract. In a second part, the use of polymeric particulate systems to improve the oral absorption of insulin is discussed.
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spelling pubmed-61475562018-11-19 Polymeric Particulates to Improve Oral Bioavailability of Peptide Drugs Delie, Florence Blanco-Príeto, María José Molecules Review Oral administration remains the most convenient way of delivering drugs. Recent advances in biotechnology have produced highly potent new molecules such as peptides, proteins and nucleic acids. Due to their sensitivity to chemical and enzymatic hydrolysis as well as a poor cellular uptake, their oral bioavailability remains very low. Despite sophisticated new delivery systems, the development of a satisfactory oral formulation remains a challenge. Among the possible strategies to improve the absorption of drugs, micro- and nanoparticles represent an exciting approach to enhance the uptake and transport of orally administered molecules. Increasing attention has been paid to their potential use as carriers for peptide drugs for oral administration. This article reviews the most common manufacturing methods for polymeric particles and the physiology of particle absorption from the gastrointestinal (GI) tract. In a second part, the use of polymeric particulate systems to improve the oral absorption of insulin is discussed. MDPI 2005-01-31 /pmc/articles/PMC6147556/ /pubmed/18007277 http://dx.doi.org/10.3390/10010065 Text en © 2005 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Review
Delie, Florence
Blanco-Príeto, María José
Polymeric Particulates to Improve Oral Bioavailability of Peptide Drugs
title Polymeric Particulates to Improve Oral Bioavailability of Peptide Drugs
title_full Polymeric Particulates to Improve Oral Bioavailability of Peptide Drugs
title_fullStr Polymeric Particulates to Improve Oral Bioavailability of Peptide Drugs
title_full_unstemmed Polymeric Particulates to Improve Oral Bioavailability of Peptide Drugs
title_short Polymeric Particulates to Improve Oral Bioavailability of Peptide Drugs
title_sort polymeric particulates to improve oral bioavailability of peptide drugs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147556/
https://www.ncbi.nlm.nih.gov/pubmed/18007277
http://dx.doi.org/10.3390/10010065
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