Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region

Synthesis of several pryrazolo[4,3-e][1,2,4]-triazines is described. The absorption spectrum of some 5-substituted derivatives was found to extend to the visible region. These compounds were found to inhibit some enzymes of purine metabolism, like xanthine oxidase or bacterial purine-nucleoside phos...

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Autores principales: Mojzych, Mariusz, Rykowski, Andrzej, Wierzchowski, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147567/
https://www.ncbi.nlm.nih.gov/pubmed/18007523
http://dx.doi.org/10.3390/10101298
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author Mojzych, Mariusz
Rykowski, Andrzej
Wierzchowski, Jacek
author_facet Mojzych, Mariusz
Rykowski, Andrzej
Wierzchowski, Jacek
author_sort Mojzych, Mariusz
collection PubMed
description Synthesis of several pryrazolo[4,3-e][1,2,4]-triazines is described. The absorption spectrum of some 5-substituted derivatives was found to extend to the visible region. These compounds were found to inhibit some enzymes of purine metabolism, like xanthine oxidase or bacterial purine-nucleoside phosphorylase with K(i) values in the 10(-3) – 10(-5) M range.
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spelling pubmed-61475672018-11-16 Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region Mojzych, Mariusz Rykowski, Andrzej Wierzchowski, Jacek Molecules Article Synthesis of several pryrazolo[4,3-e][1,2,4]-triazines is described. The absorption spectrum of some 5-substituted derivatives was found to extend to the visible region. These compounds were found to inhibit some enzymes of purine metabolism, like xanthine oxidase or bacterial purine-nucleoside phosphorylase with K(i) values in the 10(-3) – 10(-5) M range. MDPI 2005-10-31 /pmc/articles/PMC6147567/ /pubmed/18007523 http://dx.doi.org/10.3390/10101298 Text en © 2005 by MDPI (http:www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Mojzych, Mariusz
Rykowski, Andrzej
Wierzchowski, Jacek
Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region
title Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region
title_full Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region
title_fullStr Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region
title_full_unstemmed Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region
title_short Pyrazolo[4,3-e][1,2,4]triazines: Purine Analogues with Electronic Absorption in the Visible Region
title_sort pyrazolo[4,3-e][1,2,4]triazines: purine analogues with electronic absorption in the visible region
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147567/
https://www.ncbi.nlm.nih.gov/pubmed/18007523
http://dx.doi.org/10.3390/10101298
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AT wierzchowskijacek pyrazolo43e124triazinespurineanalogueswithelectronicabsorptioninthevisibleregion

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