Synthesis of Analogs of Amathamide A Their Preliminary Antimicrobial Activity

Syntheses of three non-brominated analogs of amathamide A (1), a natural alkaloid isolated from the Tasmanian marine bryozoan Amathia wilsoni, are described. Antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomona aeruginosa, and Candida albicans was tes...

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Detalles Bibliográficos
Autores principales: Ramírez-Osuna, Moisés, Chávez, Daniel, Hernández, Lourdes, Molins, Elias, Somanathan, Ratnasamy, Aguirre, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147571/
https://www.ncbi.nlm.nih.gov/pubmed/18007299
http://dx.doi.org/10.3390/10010295
Descripción
Sumario:Syntheses of three non-brominated analogs of amathamide A (1), a natural alkaloid isolated from the Tasmanian marine bryozoan Amathia wilsoni, are described. Antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomona aeruginosa, and Candida albicans was tested. Test results for amathamide A (1) showed a weak activity against C. albicans and E. coli. The three non-natural analogs 2-4 proved to be inactive compounds.

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