Synthesis of Analogs of Amathamide A Their Preliminary Antimicrobial Activity

Syntheses of three non-brominated analogs of amathamide A (1), a natural alkaloid isolated from the Tasmanian marine bryozoan Amathia wilsoni, are described. Antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomona aeruginosa, and Candida albicans was tes...

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Autores principales: Ramírez-Osuna, Moisés, Chávez, Daniel, Hernández, Lourdes, Molins, Elias, Somanathan, Ratnasamy, Aguirre, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147571/
https://www.ncbi.nlm.nih.gov/pubmed/18007299
http://dx.doi.org/10.3390/10010295
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author Ramírez-Osuna, Moisés
Chávez, Daniel
Hernández, Lourdes
Molins, Elias
Somanathan, Ratnasamy
Aguirre, Gerardo
author_facet Ramírez-Osuna, Moisés
Chávez, Daniel
Hernández, Lourdes
Molins, Elias
Somanathan, Ratnasamy
Aguirre, Gerardo
author_sort Ramírez-Osuna, Moisés
collection PubMed
description Syntheses of three non-brominated analogs of amathamide A (1), a natural alkaloid isolated from the Tasmanian marine bryozoan Amathia wilsoni, are described. Antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomona aeruginosa, and Candida albicans was tested. Test results for amathamide A (1) showed a weak activity against C. albicans and E. coli. The three non-natural analogs 2-4 proved to be inactive compounds.
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spelling pubmed-61475712018-11-19 Synthesis of Analogs of Amathamide A Their Preliminary Antimicrobial Activity Ramírez-Osuna, Moisés Chávez, Daniel Hernández, Lourdes Molins, Elias Somanathan, Ratnasamy Aguirre, Gerardo Molecules Article Syntheses of three non-brominated analogs of amathamide A (1), a natural alkaloid isolated from the Tasmanian marine bryozoan Amathia wilsoni, are described. Antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomona aeruginosa, and Candida albicans was tested. Test results for amathamide A (1) showed a weak activity against C. albicans and E. coli. The three non-natural analogs 2-4 proved to be inactive compounds. MDPI 2005-01-31 /pmc/articles/PMC6147571/ /pubmed/18007299 http://dx.doi.org/10.3390/10010295 Text en © 2005 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Ramírez-Osuna, Moisés
Chávez, Daniel
Hernández, Lourdes
Molins, Elias
Somanathan, Ratnasamy
Aguirre, Gerardo
Synthesis of Analogs of Amathamide A Their Preliminary Antimicrobial Activity
title Synthesis of Analogs of Amathamide A Their Preliminary Antimicrobial Activity
title_full Synthesis of Analogs of Amathamide A Their Preliminary Antimicrobial Activity
title_fullStr Synthesis of Analogs of Amathamide A Their Preliminary Antimicrobial Activity
title_full_unstemmed Synthesis of Analogs of Amathamide A Their Preliminary Antimicrobial Activity
title_short Synthesis of Analogs of Amathamide A Their Preliminary Antimicrobial Activity
title_sort synthesis of analogs of amathamide a their preliminary antimicrobial activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147571/
https://www.ncbi.nlm.nih.gov/pubmed/18007299
http://dx.doi.org/10.3390/10010295
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