Synthesis and Cyclizations of N-(2,3-, 3,4- and 3,5-Dimethylphenyl)-β-alanines

A series of 1-aryl substituted dihydro-, 5-methyldihydro- and 6-methyl-dihydro-2,4(1H,3H)pyrimidinediones and their 2-thio analogues were obtained by reaction of the corresponding β-alanines or α-methyl- and β-methyl-β-alanines with urea or potassium thiocyanate. The reaction of N-(2,3- and 3,5-dime...

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Autores principales: Vaickelioniene, Rita, Mickevicius, Vytautas, Mikulskiene, Gema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147616/
https://www.ncbi.nlm.nih.gov/pubmed/18007312
http://dx.doi.org/10.3390/10020407
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author Vaickelioniene, Rita
Mickevicius, Vytautas
Mikulskiene, Gema
author_facet Vaickelioniene, Rita
Mickevicius, Vytautas
Mikulskiene, Gema
author_sort Vaickelioniene, Rita
collection PubMed
description A series of 1-aryl substituted dihydro-, 5-methyldihydro- and 6-methyl-dihydro-2,4(1H,3H)pyrimidinediones and their 2-thio analogues were obtained by reaction of the corresponding β-alanines or α-methyl- and β-methyl-β-alanines with urea or potassium thiocyanate. The reaction of N-(2,3- and 3,5-dimethylphenyl)-α-methyl-β-alanines with ethyl acetoacetate gave 1-(2,3- or 3,5-dimethylphenyl)-2,5-dimethyl-1,4,5,6-tetrahydro-4(1H)pyridones. The combined spectral data obtained by (1)H-, (13)C-, (1)H/(13)C (HETCOR) NMR and IR provided useful information about the structure of the products synthesized in this work.
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spelling pubmed-61476162018-11-19 Synthesis and Cyclizations of N-(2,3-, 3,4- and 3,5-Dimethylphenyl)-β-alanines Vaickelioniene, Rita Mickevicius, Vytautas Mikulskiene, Gema Molecules Article A series of 1-aryl substituted dihydro-, 5-methyldihydro- and 6-methyl-dihydro-2,4(1H,3H)pyrimidinediones and their 2-thio analogues were obtained by reaction of the corresponding β-alanines or α-methyl- and β-methyl-β-alanines with urea or potassium thiocyanate. The reaction of N-(2,3- and 3,5-dimethylphenyl)-α-methyl-β-alanines with ethyl acetoacetate gave 1-(2,3- or 3,5-dimethylphenyl)-2,5-dimethyl-1,4,5,6-tetrahydro-4(1H)pyridones. The combined spectral data obtained by (1)H-, (13)C-, (1)H/(13)C (HETCOR) NMR and IR provided useful information about the structure of the products synthesized in this work. MDPI 2005-02-28 /pmc/articles/PMC6147616/ /pubmed/18007312 http://dx.doi.org/10.3390/10020407 Text en © 2005 by MDPI (http:www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Vaickelioniene, Rita
Mickevicius, Vytautas
Mikulskiene, Gema
Synthesis and Cyclizations of N-(2,3-, 3,4- and 3,5-Dimethylphenyl)-β-alanines
title Synthesis and Cyclizations of N-(2,3-, 3,4- and 3,5-Dimethylphenyl)-β-alanines
title_full Synthesis and Cyclizations of N-(2,3-, 3,4- and 3,5-Dimethylphenyl)-β-alanines
title_fullStr Synthesis and Cyclizations of N-(2,3-, 3,4- and 3,5-Dimethylphenyl)-β-alanines
title_full_unstemmed Synthesis and Cyclizations of N-(2,3-, 3,4- and 3,5-Dimethylphenyl)-β-alanines
title_short Synthesis and Cyclizations of N-(2,3-, 3,4- and 3,5-Dimethylphenyl)-β-alanines
title_sort synthesis and cyclizations of n-(2,3-, 3,4- and 3,5-dimethylphenyl)-β-alanines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147616/
https://www.ncbi.nlm.nih.gov/pubmed/18007312
http://dx.doi.org/10.3390/10020407
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