Synthesis of the Key Precursor of Hirsutellide A

Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)p...

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Autores principales: Xu, Yanjie, Duan, Xuemin, Li, Meiling, Jiang, Liqin, Zhao, Guangle, Meng, Yi, Chen, Ligong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147622/
https://www.ncbi.nlm.nih.gov/pubmed/18007294
http://dx.doi.org/10.3390/10010259
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author Xu, Yanjie
Duan, Xuemin
Li, Meiling
Jiang, Liqin
Zhao, Guangle
Meng, Yi
Chen, Ligong
author_facet Xu, Yanjie
Duan, Xuemin
Li, Meiling
Jiang, Liqin
Zhao, Guangle
Meng, Yi
Chen, Ligong
author_sort Xu, Yanjie
collection PubMed
description Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively.
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spelling pubmed-61476222018-11-19 Synthesis of the Key Precursor of Hirsutellide A Xu, Yanjie Duan, Xuemin Li, Meiling Jiang, Liqin Zhao, Guangle Meng, Yi Chen, Ligong Molecules Article Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively. MDPI 2005-01-31 /pmc/articles/PMC6147622/ /pubmed/18007294 http://dx.doi.org/10.3390/10010259 Text en © 2005 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Xu, Yanjie
Duan, Xuemin
Li, Meiling
Jiang, Liqin
Zhao, Guangle
Meng, Yi
Chen, Ligong
Synthesis of the Key Precursor of Hirsutellide A
title Synthesis of the Key Precursor of Hirsutellide A
title_full Synthesis of the Key Precursor of Hirsutellide A
title_fullStr Synthesis of the Key Precursor of Hirsutellide A
title_full_unstemmed Synthesis of the Key Precursor of Hirsutellide A
title_short Synthesis of the Key Precursor of Hirsutellide A
title_sort synthesis of the key precursor of hirsutellide a
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147622/
https://www.ncbi.nlm.nih.gov/pubmed/18007294
http://dx.doi.org/10.3390/10010259
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AT jiangliqin synthesisofthekeyprecursorofhirsutellidea
AT zhaoguangle synthesisofthekeyprecursorofhirsutellidea
AT mengyi synthesisofthekeyprecursorofhirsutellidea
AT chenligong synthesisofthekeyprecursorofhirsutellidea

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