Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator

Urea-hydrogen peroxide (UHP) was used in the presence of maleic anhydride as mediator in a simple and convenient method for the oxidation in high yield of some thiols to the corresponding disulfides. Peroxymaleic acid formed in situ from the reaction of UHP with maleic anhydride has a key role in th...

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Detalles Bibliográficos
Autores principales: Karami, Bahador, Montazerozohori, M., Habibi, M. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147623/
https://www.ncbi.nlm.nih.gov/pubmed/18007530
http://dx.doi.org/10.3390/10101385
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author Karami, Bahador
Montazerozohori, M.
Habibi, M. H.
author_facet Karami, Bahador
Montazerozohori, M.
Habibi, M. H.
author_sort Karami, Bahador
collection PubMed
description Urea-hydrogen peroxide (UHP) was used in the presence of maleic anhydride as mediator in a simple and convenient method for the oxidation in high yield of some thiols to the corresponding disulfides. Peroxymaleic acid formed in situ from the reaction of UHP with maleic anhydride has a key role in this oxidation. Performance of the reaction in various solvents showed that methanol was the solvent of choice at 0 (o)C. The products were isolated by simple filtration on silica gel.
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spelling pubmed-61476232018-11-16 Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator Karami, Bahador Montazerozohori, M. Habibi, M. H. Molecules Article Urea-hydrogen peroxide (UHP) was used in the presence of maleic anhydride as mediator in a simple and convenient method for the oxidation in high yield of some thiols to the corresponding disulfides. Peroxymaleic acid formed in situ from the reaction of UHP with maleic anhydride has a key role in this oxidation. Performance of the reaction in various solvents showed that methanol was the solvent of choice at 0 (o)C. The products were isolated by simple filtration on silica gel. MDPI 2005-10-31 /pmc/articles/PMC6147623/ /pubmed/18007530 http://dx.doi.org/10.3390/10101385 Text en © 2005 by MDPI (http:www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Karami, Bahador
Montazerozohori, M.
Habibi, M. H.
Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator
title Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator
title_full Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator
title_fullStr Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator
title_full_unstemmed Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator
title_short Urea- Hydrogen Peroxide (UHP) Oxidation of Thiols to the Corresponding Disulfides Promoted by Maleic Anhydride as Mediator
title_sort urea- hydrogen peroxide (uhp) oxidation of thiols to the corresponding disulfides promoted by maleic anhydride as mediator
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147623/
https://www.ncbi.nlm.nih.gov/pubmed/18007530
http://dx.doi.org/10.3390/10101385
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AT habibimh ureahydrogenperoxideuhpoxidationofthiolstothecorrespondingdisulfidespromotedbymaleicanhydrideasmediator

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