AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy

The aim of this study was to synthesize novel biodegradable charged polymers to be used in DNA complexation for genetic delivery in different diseases. A new copolymer of PLA and complexed Schiff bases was synthesized in a several steps. This copolymer will be used as a nanocarrier. Also, AFM compar...

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Detalles Bibliográficos
Autores principales: Nadeau, Véronique, Hildgen, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147626/
https://www.ncbi.nlm.nih.gov/pubmed/18007280
http://dx.doi.org/10.3390/10010105
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author Nadeau, Véronique
Hildgen, Patrice
author_facet Nadeau, Véronique
Hildgen, Patrice
author_sort Nadeau, Véronique
collection PubMed
description The aim of this study was to synthesize novel biodegradable charged polymers to be used in DNA complexation for genetic delivery in different diseases. A new copolymer of PLA and complexed Schiff bases was synthesized in a several steps. This copolymer will be used as a nanocarrier. Also, AFM comparative studies in tapping mode were performed; on cationic copolymer and on PLA-Schiff base copolymer, on non-oriented and oriented film and on the DNA-cationic complex. The results indicated a difference in the topology and on phase picture of AFM film with or without cationic charge.
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spelling pubmed-61476262018-11-19 AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy Nadeau, Véronique Hildgen, Patrice Molecules Article The aim of this study was to synthesize novel biodegradable charged polymers to be used in DNA complexation for genetic delivery in different diseases. A new copolymer of PLA and complexed Schiff bases was synthesized in a several steps. This copolymer will be used as a nanocarrier. Also, AFM comparative studies in tapping mode were performed; on cationic copolymer and on PLA-Schiff base copolymer, on non-oriented and oriented film and on the DNA-cationic complex. The results indicated a difference in the topology and on phase picture of AFM film with or without cationic charge. MDPI 2005-01-31 /pmc/articles/PMC6147626/ /pubmed/18007280 http://dx.doi.org/10.3390/10010105 Text en © 2005 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Nadeau, Véronique
Hildgen, Patrice
AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy
title AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy
title_full AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy
title_fullStr AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy
title_full_unstemmed AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy
title_short AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy
title_sort afm study of a new carrier based on pla and salen copolymers for gene therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147626/
https://www.ncbi.nlm.nih.gov/pubmed/18007280
http://dx.doi.org/10.3390/10010105
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