Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity

A series of lipophilic 2-substituted 5,7-di-tert-butylbenzoxazoles was prepared in average yields by the reaction of 3,5-di-tert-butyl-1,2-benzoquinone with amino acids and dipeptides bearing N-terminal glycine. Dipeptides having other N-terminal amino acids undergo oxidative deamination. 5,7-Di-ter...

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Autores principales: Vinšová, Jarmila, Horák, Václav, Buchta, Vladimír, Kaustová, Jarmila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147629/
https://www.ncbi.nlm.nih.gov/pubmed/18007347
http://dx.doi.org/10.3390/10070783
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author Vinšová, Jarmila
Horák, Václav
Buchta, Vladimír
Kaustová, Jarmila
author_facet Vinšová, Jarmila
Horák, Václav
Buchta, Vladimír
Kaustová, Jarmila
author_sort Vinšová, Jarmila
collection PubMed
description A series of lipophilic 2-substituted 5,7-di-tert-butylbenzoxazoles was prepared in average yields by the reaction of 3,5-di-tert-butyl-1,2-benzoquinone with amino acids and dipeptides bearing N-terminal glycine. Dipeptides having other N-terminal amino acids undergo oxidative deamination. 5,7-Di-tert-butylbenzoxazoles have shown activity against Mycobacterium tuberculosis and some nontuberculous strains where isoniazid has been inactive. Antifungal activity was mediocre.
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spelling pubmed-61476292018-11-19 Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity Vinšová, Jarmila Horák, Václav Buchta, Vladimír Kaustová, Jarmila Molecules Article A series of lipophilic 2-substituted 5,7-di-tert-butylbenzoxazoles was prepared in average yields by the reaction of 3,5-di-tert-butyl-1,2-benzoquinone with amino acids and dipeptides bearing N-terminal glycine. Dipeptides having other N-terminal amino acids undergo oxidative deamination. 5,7-Di-tert-butylbenzoxazoles have shown activity against Mycobacterium tuberculosis and some nontuberculous strains where isoniazid has been inactive. Antifungal activity was mediocre. MDPI 2005-08-31 /pmc/articles/PMC6147629/ /pubmed/18007347 http://dx.doi.org/10.3390/10070783 Text en © 2005 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Vinšová, Jarmila
Horák, Václav
Buchta, Vladimír
Kaustová, Jarmila
Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity
title Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity
title_full Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity
title_fullStr Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity
title_full_unstemmed Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity
title_short Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity
title_sort highly lipophilic benzoxazoles with potential antibacterial activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147629/
https://www.ncbi.nlm.nih.gov/pubmed/18007347
http://dx.doi.org/10.3390/10070783
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AT kaustovajarmila highlylipophilicbenzoxazoleswithpotentialantibacterialactivity

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