Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues

Aryl free-radicals generated at the C-7 position of ethyl indole-2-carboxylates bearing N-allyl and propargylic groups triggered intramolecular cyclizations to furnish a new class of Duocarmycin analogues, formal ethyl pyrrolo[3,2,1-ij]quinoline-2-carboxylate derivatives, through the less favorable...

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Autores principales: Al-Said, Naim H., Shawakfeh, Khaled Q., Abdullah, Wasim N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147633/
https://www.ncbi.nlm.nih.gov/pubmed/18007541
http://dx.doi.org/10.3390/10121446
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author Al-Said, Naim H.
Shawakfeh, Khaled Q.
Abdullah, Wasim N.
author_facet Al-Said, Naim H.
Shawakfeh, Khaled Q.
Abdullah, Wasim N.
author_sort Al-Said, Naim H.
collection PubMed
description Aryl free-radicals generated at the C-7 position of ethyl indole-2-carboxylates bearing N-allyl and propargylic groups triggered intramolecular cyclizations to furnish a new class of Duocarmycin analogues, formal ethyl pyrrolo[3,2,1-ij]quinoline-2-carboxylate derivatives, through the less favorable 6-endo-trig cyclization mode.
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spelling pubmed-61476332018-11-16 Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues Al-Said, Naim H. Shawakfeh, Khaled Q. Abdullah, Wasim N. Molecules Article Aryl free-radicals generated at the C-7 position of ethyl indole-2-carboxylates bearing N-allyl and propargylic groups triggered intramolecular cyclizations to furnish a new class of Duocarmycin analogues, formal ethyl pyrrolo[3,2,1-ij]quinoline-2-carboxylate derivatives, through the less favorable 6-endo-trig cyclization mode. MDPI 2005-12-31 /pmc/articles/PMC6147633/ /pubmed/18007541 http://dx.doi.org/10.3390/10121446 Text en © 2005 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Al-Said, Naim H.
Shawakfeh, Khaled Q.
Abdullah, Wasim N.
Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues
title Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues
title_full Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues
title_fullStr Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues
title_full_unstemmed Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues
title_short Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues
title_sort cyclization of free radicals at the c-7 position of ethyl indole–2-carboxylate derivatives: an entry to a new class of duocarmycin analogues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147633/
https://www.ncbi.nlm.nih.gov/pubmed/18007541
http://dx.doi.org/10.3390/10121446
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