Synthesis of Some Phenylpropanoid Monoglycerides via the Mitsunobu Protocol

Natural monoglycerides of cinnamic, ferulic and p-coumaric acids were synthesized in good to high overall yields from isopropylidene glycerol via the Mitsunobu reaction and further deprotection of the corresponding acetonides with Amberlyst 15. The method avoids the need of protection of the phenoli...

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Detalles Bibliográficos
Autores principales: Batovska, Daniela I., Kishimoto, Takao, Bankova, Vassya S., Kamenarska, Zornitsa G., Ubukata, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147682/
https://www.ncbi.nlm.nih.gov/pubmed/18007328
http://dx.doi.org/10.3390/10030552
Descripción
Sumario:Natural monoglycerides of cinnamic, ferulic and p-coumaric acids were synthesized in good to high overall yields from isopropylidene glycerol via the Mitsunobu reaction and further deprotection of the corresponding acetonides with Amberlyst 15. The method avoids the need of protection of the phenolic hydroxyls. During the Mitsunobu esterifications a strong influence of the acid strength on the efficacy and outcome of the reaction was observed.

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