A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation

A facile synthesis of 3-methylthio-3-arylamino-2-cyanoacrylates from 3,3-dimethylthioacrylate and aromatic amines or amino pyridines has been achieved in moderate to high yields (64.0% ~ 93.5%) in 30 minutes at 50°C under microwave irradiation. This method is very simple and the reaction conditions...

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Detalles Bibliográficos
Autores principales: Ouyang, Guiping, Song, Baoan, Zhang, Huiping, Yang, Song, Jin, Linhong, Li, Qianzhu, Hu, Deyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147691/
https://www.ncbi.nlm.nih.gov/pubmed/18007529
http://dx.doi.org/10.3390/10101351
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author Ouyang, Guiping
Song, Baoan
Zhang, Huiping
Yang, Song
Jin, Linhong
Li, Qianzhu
Hu, Deyu
author_facet Ouyang, Guiping
Song, Baoan
Zhang, Huiping
Yang, Song
Jin, Linhong
Li, Qianzhu
Hu, Deyu
author_sort Ouyang, Guiping
collection PubMed
description A facile synthesis of 3-methylthio-3-arylamino-2-cyanoacrylates from 3,3-dimethylthioacrylate and aromatic amines or amino pyridines has been achieved in moderate to high yields (64.0% ~ 93.5%) in 30 minutes at 50°C under microwave irradiation. This method is very simple and the reaction conditions are mild, environmentally friendly and more importantly, quick. In the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, some of the title compounds were found to possess good antiproliferation activity towards PC3 cells.
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spelling pubmed-61476912018-11-16 A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation Ouyang, Guiping Song, Baoan Zhang, Huiping Yang, Song Jin, Linhong Li, Qianzhu Hu, Deyu Molecules Article A facile synthesis of 3-methylthio-3-arylamino-2-cyanoacrylates from 3,3-dimethylthioacrylate and aromatic amines or amino pyridines has been achieved in moderate to high yields (64.0% ~ 93.5%) in 30 minutes at 50°C under microwave irradiation. This method is very simple and the reaction conditions are mild, environmentally friendly and more importantly, quick. In the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, some of the title compounds were found to possess good antiproliferation activity towards PC3 cells. MDPI 2005-10-31 /pmc/articles/PMC6147691/ /pubmed/18007529 http://dx.doi.org/10.3390/10101351 Text en © 2005 by MDPI (http:www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Ouyang, Guiping
Song, Baoan
Zhang, Huiping
Yang, Song
Jin, Linhong
Li, Qianzhu
Hu, Deyu
A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation
title A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation
title_full A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation
title_fullStr A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation
title_full_unstemmed A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation
title_short A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino-2-Cyanoacrylates under Microwave Irradiation
title_sort novel synthesis of (e)-3-methylthio-3-substituted arylamino-2-cyanoacrylates under microwave irradiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147691/
https://www.ncbi.nlm.nih.gov/pubmed/18007529
http://dx.doi.org/10.3390/10101351
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