Pyrimidine Acyclo-C-Nucleosides by Ring Transformations of 2-Formyl-L-arabinal

The protected 2-formyl-L-arabinal 2 reacted with thiourea and cyanamide in the presence of sodium hydride to afford via ring transformations the 5-[1R,2S-1,2-bis(benzyloxy)-3-hydroxypropyl]-1,2-dihydropyrimidines 3 and 4, respectively. Similarly, treatment of 2 with 3-amino-2H-1,2,4-triazole yielded...

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Autores principales: Bari, Ahmed, Feist, Holger, Michalik, Manfred, Peseke, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147699/
https://www.ncbi.nlm.nih.gov/pubmed/18007353
http://dx.doi.org/10.3390/10080837
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author Bari, Ahmed
Feist, Holger
Michalik, Manfred
Peseke, Klaus
author_facet Bari, Ahmed
Feist, Holger
Michalik, Manfred
Peseke, Klaus
author_sort Bari, Ahmed
collection PubMed
description The protected 2-formyl-L-arabinal 2 reacted with thiourea and cyanamide in the presence of sodium hydride to afford via ring transformations the 5-[1R,2S-1,2-bis(benzyloxy)-3-hydroxypropyl]-1,2-dihydropyrimidines 3 and 4, respectively. Similarly, treatment of 2 with 3-amino-2H-1,2,4-triazole yielded 6-[1R,2S-1,2-bis(benzyloxy)-3-hydroxypropyl][1,2,4]-triazolo[1,5-a]pyrimidine (5).
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spelling pubmed-61476992018-11-19 Pyrimidine Acyclo-C-Nucleosides by Ring Transformations of 2-Formyl-L-arabinal Bari, Ahmed Feist, Holger Michalik, Manfred Peseke, Klaus Molecules Article The protected 2-formyl-L-arabinal 2 reacted with thiourea and cyanamide in the presence of sodium hydride to afford via ring transformations the 5-[1R,2S-1,2-bis(benzyloxy)-3-hydroxypropyl]-1,2-dihydropyrimidines 3 and 4, respectively. Similarly, treatment of 2 with 3-amino-2H-1,2,4-triazole yielded 6-[1R,2S-1,2-bis(benzyloxy)-3-hydroxypropyl][1,2,4]-triazolo[1,5-a]pyrimidine (5). MDPI 2005-08-31 /pmc/articles/PMC6147699/ /pubmed/18007353 http://dx.doi.org/10.3390/10080837 Text en © 2005 by MDPI (http://www.mdpi.org). Reproduction is permitted for non commercial purposes.
spellingShingle Article
Bari, Ahmed
Feist, Holger
Michalik, Manfred
Peseke, Klaus
Pyrimidine Acyclo-C-Nucleosides by Ring Transformations of 2-Formyl-L-arabinal
title Pyrimidine Acyclo-C-Nucleosides by Ring Transformations of 2-Formyl-L-arabinal
title_full Pyrimidine Acyclo-C-Nucleosides by Ring Transformations of 2-Formyl-L-arabinal
title_fullStr Pyrimidine Acyclo-C-Nucleosides by Ring Transformations of 2-Formyl-L-arabinal
title_full_unstemmed Pyrimidine Acyclo-C-Nucleosides by Ring Transformations of 2-Formyl-L-arabinal
title_short Pyrimidine Acyclo-C-Nucleosides by Ring Transformations of 2-Formyl-L-arabinal
title_sort pyrimidine acyclo-c-nucleosides by ring transformations of 2-formyl-l-arabinal
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147699/
https://www.ncbi.nlm.nih.gov/pubmed/18007353
http://dx.doi.org/10.3390/10080837
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