Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS

Due to recent advances in disease proteomics, many disease-related proteins have been found. It is expected that there will be therapeutically useful proteins among them. However, it is clinically difficult to use most proteins as effective and safe drugs because of their very low stability and plei...

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Detalles Bibliográficos
Autores principales: Shibata, Hiroko, Nakagawa, Shinsaku, Tsutsumi, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2005
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147742/
https://www.ncbi.nlm.nih.gov/pubmed/18007284
http://dx.doi.org/10.3390/10010162
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author Shibata, Hiroko
Nakagawa, Shinsaku
Tsutsumi, Yasuo
author_facet Shibata, Hiroko
Nakagawa, Shinsaku
Tsutsumi, Yasuo
author_sort Shibata, Hiroko
collection PubMed
description Due to recent advances in disease proteomics, many disease-related proteins have been found. It is expected that there will be therapeutically useful proteins among them. However, it is clinically difficult to use most proteins as effective and safe drugs because of their very low stability and pleiotropic actions in vivo. To promote disease proteomic based drug development for protein therapies, we have attempted to develop an optimal polymer-conjugation system for improving the therapeutic potency of proteins. In this review, we introduce this innovative protein-drug system.
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spelling pubmed-61477422018-11-19 Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS Shibata, Hiroko Nakagawa, Shinsaku Tsutsumi, Yasuo Molecules Review Due to recent advances in disease proteomics, many disease-related proteins have been found. It is expected that there will be therapeutically useful proteins among them. However, it is clinically difficult to use most proteins as effective and safe drugs because of their very low stability and pleiotropic actions in vivo. To promote disease proteomic based drug development for protein therapies, we have attempted to develop an optimal polymer-conjugation system for improving the therapeutic potency of proteins. In this review, we introduce this innovative protein-drug system. MDPI 2005-01-31 /pmc/articles/PMC6147742/ /pubmed/18007284 http://dx.doi.org/10.3390/10010162 Text en © 2005 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Review
Shibata, Hiroko
Nakagawa, Shinsaku
Tsutsumi, Yasuo
Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS
title Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS
title_full Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS
title_fullStr Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS
title_full_unstemmed Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS
title_short Optimization of Protein Therapies by Polymer-Conjugation as an Effective DDS
title_sort optimization of protein therapies by polymer-conjugation as an effective dds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147742/
https://www.ncbi.nlm.nih.gov/pubmed/18007284
http://dx.doi.org/10.3390/10010162
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AT tsutsumiyasuo optimizationofproteintherapiesbypolymerconjugationasaneffectivedds

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