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Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis()

OBJECTIVE: To assess the effects of atorvastatin calcium in the treatment of dexamethasone-induced osteoporosis. METHODS: Osteoporosis induction consisted of the administration of an intramuscular dose of 7.5 mg/kg of body weight of dexamethasone, once a week for four weeks, except for the control a...

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Autores principales: Ferreira Junior, Davilson Bragine, Pizziolo, Virgínia Ramos, Oliveira, Tânia Toledo de, Matta, Sérgio Luis Pinto da, Píccolo, Mayra Soares, Queiroz, José Humberto de
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147763/
https://www.ncbi.nlm.nih.gov/pubmed/30245999
http://dx.doi.org/10.1016/j.rboe.2018.07.007
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author Ferreira Junior, Davilson Bragine
Pizziolo, Virgínia Ramos
Oliveira, Tânia Toledo de
Matta, Sérgio Luis Pinto da
Píccolo, Mayra Soares
Queiroz, José Humberto de
author_facet Ferreira Junior, Davilson Bragine
Pizziolo, Virgínia Ramos
Oliveira, Tânia Toledo de
Matta, Sérgio Luis Pinto da
Píccolo, Mayra Soares
Queiroz, José Humberto de
author_sort Ferreira Junior, Davilson Bragine
collection PubMed
description OBJECTIVE: To assess the effects of atorvastatin calcium in the treatment of dexamethasone-induced osteoporosis. METHODS: Osteoporosis induction consisted of the administration of an intramuscular dose of 7.5 mg/kg of body weight of dexamethasone, once a week for four weeks, except for the control animals (G1). The animals were divided into the following groups: G1 (control group without osteoporosis), G2 (control group with untreated osteoporosis), G3 (control group with osteoporosis treated with sodium alendronate 0.2 mg/kg) and G4 (group with osteoporosis treated with atorvastatin calcium 1.2 mg/kg). Serum alkaline phosphatase, bone alkaline phosphatase, and biometric and bone histomorphometric assessments were performed after 30 and 60 days of treatment onset. RESULTS: In relation to the biometric and histomorphometric analyses, at 60 days of treatment, G4 presented bone density (Seedor index), bone trabecular density, and cortical thickness of 0.222 ± 0.004 g/cm, 59.167 ± 2.401%, and 387,501 ± 8573 μm, respectively, with a positive and statistically significant difference (p < 0.05), in relation to G2. At 30 and 60 days of treatment, G4 presented statistically significant serum levels of alkaline phosphatase alkaline phosphatase (p < 0.05) that were higher than all groups (7.451 ± 0.173 μg/L and 7.473 ± 0.529 μg/L, respectively). CONCLUSION: Treatment with atorvastatin calcium demonstrated the ability of this drug to increase osteoblastic activity and bone tissue repair activity, acting differently from alendronate sodium, which demonstrated predominantly antirebsorptive activity.
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spelling pubmed-61477632018-09-21 Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis() Ferreira Junior, Davilson Bragine Pizziolo, Virgínia Ramos Oliveira, Tânia Toledo de Matta, Sérgio Luis Pinto da Píccolo, Mayra Soares Queiroz, José Humberto de Rev Bras Ortop Original Article OBJECTIVE: To assess the effects of atorvastatin calcium in the treatment of dexamethasone-induced osteoporosis. METHODS: Osteoporosis induction consisted of the administration of an intramuscular dose of 7.5 mg/kg of body weight of dexamethasone, once a week for four weeks, except for the control animals (G1). The animals were divided into the following groups: G1 (control group without osteoporosis), G2 (control group with untreated osteoporosis), G3 (control group with osteoporosis treated with sodium alendronate 0.2 mg/kg) and G4 (group with osteoporosis treated with atorvastatin calcium 1.2 mg/kg). Serum alkaline phosphatase, bone alkaline phosphatase, and biometric and bone histomorphometric assessments were performed after 30 and 60 days of treatment onset. RESULTS: In relation to the biometric and histomorphometric analyses, at 60 days of treatment, G4 presented bone density (Seedor index), bone trabecular density, and cortical thickness of 0.222 ± 0.004 g/cm, 59.167 ± 2.401%, and 387,501 ± 8573 μm, respectively, with a positive and statistically significant difference (p < 0.05), in relation to G2. At 30 and 60 days of treatment, G4 presented statistically significant serum levels of alkaline phosphatase alkaline phosphatase (p < 0.05) that were higher than all groups (7.451 ± 0.173 μg/L and 7.473 ± 0.529 μg/L, respectively). CONCLUSION: Treatment with atorvastatin calcium demonstrated the ability of this drug to increase osteoblastic activity and bone tissue repair activity, acting differently from alendronate sodium, which demonstrated predominantly antirebsorptive activity. Elsevier 2018-07-27 /pmc/articles/PMC6147763/ /pubmed/30245999 http://dx.doi.org/10.1016/j.rboe.2018.07.007 Text en © 2017 Sociedade Brasileira de Ortopedia e Traumatologia. Published by Elsevier Editora Ltda. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Ferreira Junior, Davilson Bragine
Pizziolo, Virgínia Ramos
Oliveira, Tânia Toledo de
Matta, Sérgio Luis Pinto da
Píccolo, Mayra Soares
Queiroz, José Humberto de
Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis()
title Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis()
title_full Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis()
title_fullStr Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis()
title_full_unstemmed Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis()
title_short Biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis()
title_sort biometric, histomorphometric, and biochemical profile in atorvastatin calcium treatment of female rats with dexamethasone-induced osteoporosis()
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147763/
https://www.ncbi.nlm.nih.gov/pubmed/30245999
http://dx.doi.org/10.1016/j.rboe.2018.07.007
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