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Multi-color lasing in chemically open droplet cavities
In this paper, we demonstrate FRET-based multicolor lasing within chemically open droplet cavities that allow online modulation of the gain medium composition. To do this, we generated monodisperse microfluidic droplets loaded with coumarin 102 (donor), where the spherical droplets acted as whisperi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147796/ https://www.ncbi.nlm.nih.gov/pubmed/30237486 http://dx.doi.org/10.1038/s41598-018-32596-8 |
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author | Zheng, Lu Zhi, Min Chan, Yinthai Khan, Saif A. |
author_facet | Zheng, Lu Zhi, Min Chan, Yinthai Khan, Saif A. |
author_sort | Zheng, Lu |
collection | PubMed |
description | In this paper, we demonstrate FRET-based multicolor lasing within chemically open droplet cavities that allow online modulation of the gain medium composition. To do this, we generated monodisperse microfluidic droplets loaded with coumarin 102 (donor), where the spherical droplets acted as whispering gallery mode (WGM) optical cavities in which coumarin 102 lasing (~ 470 nm) was observed. The lasing color was switched from blue to orange by the introduction of a second dye (acceptor, rhodamine 6 G) into the flowing droplet cavities; subsequent lasing from rhodamine 6 G (~ 590 nm) was observed together with the complete absence of coumarin 102 emission. The ability to control color switching online within the same droplet cavity enables sequential detection of multiple target molecules within or around the cavity. As a demonstration of this concept, we show how the presence of FITC-Dextran and methylene blue (MB) in the medium surrounding the lasing droplets can be sequentially detected by the blue and orange laser respectively. The method is simple and can be extended to a range of water-soluble dyes, thus enabling a wide spectral range for the lasing with the use of a single pump laser source. |
format | Online Article Text |
id | pubmed-6147796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61477962019-02-12 Multi-color lasing in chemically open droplet cavities Zheng, Lu Zhi, Min Chan, Yinthai Khan, Saif A. Sci Rep Article In this paper, we demonstrate FRET-based multicolor lasing within chemically open droplet cavities that allow online modulation of the gain medium composition. To do this, we generated monodisperse microfluidic droplets loaded with coumarin 102 (donor), where the spherical droplets acted as whispering gallery mode (WGM) optical cavities in which coumarin 102 lasing (~ 470 nm) was observed. The lasing color was switched from blue to orange by the introduction of a second dye (acceptor, rhodamine 6 G) into the flowing droplet cavities; subsequent lasing from rhodamine 6 G (~ 590 nm) was observed together with the complete absence of coumarin 102 emission. The ability to control color switching online within the same droplet cavity enables sequential detection of multiple target molecules within or around the cavity. As a demonstration of this concept, we show how the presence of FITC-Dextran and methylene blue (MB) in the medium surrounding the lasing droplets can be sequentially detected by the blue and orange laser respectively. The method is simple and can be extended to a range of water-soluble dyes, thus enabling a wide spectral range for the lasing with the use of a single pump laser source. Nature Publishing Group UK 2018-09-20 /pmc/articles/PMC6147796/ /pubmed/30237486 http://dx.doi.org/10.1038/s41598-018-32596-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zheng, Lu Zhi, Min Chan, Yinthai Khan, Saif A. Multi-color lasing in chemically open droplet cavities |
title | Multi-color lasing in chemically open droplet cavities |
title_full | Multi-color lasing in chemically open droplet cavities |
title_fullStr | Multi-color lasing in chemically open droplet cavities |
title_full_unstemmed | Multi-color lasing in chemically open droplet cavities |
title_short | Multi-color lasing in chemically open droplet cavities |
title_sort | multi-color lasing in chemically open droplet cavities |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147796/ https://www.ncbi.nlm.nih.gov/pubmed/30237486 http://dx.doi.org/10.1038/s41598-018-32596-8 |
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