Cellular Depletion of BRD8 Causes p53-Dependent Apoptosis and Induces a DNA Damage Response in Non-Stressed Cells

Regulation of the chromatin state is crucial for biological processes such as the regulation of transcription, DNA replication, and DNA damage repair. Here we show that knockdown of the BRD8 bromodomain protein – a subunit of the p400/Tip60 complex - leads to p21 induction, and concomitant cell cycl...

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Detalles Bibliográficos
Autores principales: Lashgari, Anahita, Fauteux, Myriam, Maréchal, Alexandre, Gaudreau, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147888/
https://www.ncbi.nlm.nih.gov/pubmed/30237520
http://dx.doi.org/10.1038/s41598-018-32323-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147888/
https://www.ncbi.nlm.nih.gov/pubmed/30237520
http://dx.doi.org/10.1038/s41598-018-32323-3

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