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Impact of Porphyromonas gingivalis Peptidylarginine Deiminase on Bacterial Biofilm Formation, Epithelial Cell Invasion, and Epithelial Cell Transcriptional Landscape
Peptidylarginine deiminase (PPAD) is a virulence factor unique to pathogenic Porphyromonas species, especially P. gingivalis. Mechanistically, PPAD activity, in conjunction with Arg-specific gingipains, generates protein fragments with citrullinated C-termini. Such polypeptides are potential de novo...
Autores principales: | Aliko, Ardita, Kamińska, Marta, Bergum, Brith, Gawron, Katarzyna, Benedyk, Małgorzata, Lamont, Richard J., Malicki, Stanisław, Delaleu, Nicolas, Potempa, Jan, Mydel, Piotr |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147916/ https://www.ncbi.nlm.nih.gov/pubmed/30237466 http://dx.doi.org/10.1038/s41598-018-32603-y |
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