p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis

The tumor suppressor p53 has critical roles in regulating lipid metabolism, but whether and how p53 regulates cardiolipin (CL) de novo biosynthesis is unknown. Here, we report that p53 physically interacts with histone deacetylase SIRT6 in vitro and in vivo, and this interaction increases following...

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Detalles Bibliográficos
Autores principales: Li, Meiting, Hou, Tianyun, Gao, Tian, Lu, Xiaopeng, Yang, Qiaoyan, Zhu, Qian, Li, Zhiming, Liu, Chaohua, Mu, Guanqun, Liu, Ge, Bao, Yantao, Wen, He, Wang, Lina, Wang, Haiying, Zhao, Ying, Gu, Wei, Yang, Yang, Zhu, Wei-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148051/
https://www.ncbi.nlm.nih.gov/pubmed/30237540
http://dx.doi.org/10.1038/s41419-018-0984-0

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