MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis

Glycine N-methyltransferase (GNMT) is the most abundant methyltransferase in the liver and a master regulator of the transmethylation flux. GNMT downregulation leads to loss of liver function progressing to fibrosis, cirrhosis, and hepatocellular carcinoma. Moreover, GNMT deficiency aggravates chole...

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Detalles Bibliográficos
Autores principales: Fernández-Ramos, David, Fernández-Tussy, Pablo, Lopitz-Otsoa, Fernando, Gutiérrez-de-Juan, Virginia, Navasa, Nicolás, Barbier-Torres, Lucía, Zubiete-Franco, Imanol, Simón, Jorge, Fernández, Agustín F., Arbelaiz, Ander, Aransay, Ana M., Lavín, José Luis, Beraza, Naiara, Perugorria, María J., Banales, Jesus M., Villa, Erica, Fraga, Mario F., Anguita, Juan, Avila, Matias A., Berasain, Carmen, Iruzibieta, Paula, Crespo, Javier, Lu, Shelly C., Varela-Rey, Marta, Mato, José M., Delgado, Teresa C., Martínez-Chantar, María L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148053/
https://www.ncbi.nlm.nih.gov/pubmed/30237481
http://dx.doi.org/10.1038/s41419-018-1014-y

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