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Multimodality Therapy Including Proton Beam Therapy for AFP Producing Esophageal Cancer with Multiple Liver Metastases

A 50-year-old man who presented with a fever and epigastralgia was diagnosed to have esophageal carcinoma which was identified as poorly differentiated adenocarcinoma producing alpha-fetoprotein (AFP) with Barrett's esophagus. Computed tomography revealed multiple liver metastases and lymph nod...

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Autores principales: Miyazaki, Tatsuya, Sohda, Makoto, Sakai, Makoto, Kumakura, Yuji, Yoshida, Tomonori, Kuriyama, Kengo, Yokobori, Takehiko, Miyazaki, Masaya, Hirato, Junko, Okumura, Toshiyuki, Ishikawa, Hitoshi, Sakurai, Hideyuki, Kuwano, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148179/
https://www.ncbi.nlm.nih.gov/pubmed/29607947
http://dx.doi.org/10.2169/internalmedicine.0270-17
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author Miyazaki, Tatsuya
Sohda, Makoto
Sakai, Makoto
Kumakura, Yuji
Yoshida, Tomonori
Kuriyama, Kengo
Yokobori, Takehiko
Miyazaki, Masaya
Hirato, Junko
Okumura, Toshiyuki
Ishikawa, Hitoshi
Sakurai, Hideyuki
Kuwano, Hiroyuki
author_facet Miyazaki, Tatsuya
Sohda, Makoto
Sakai, Makoto
Kumakura, Yuji
Yoshida, Tomonori
Kuriyama, Kengo
Yokobori, Takehiko
Miyazaki, Masaya
Hirato, Junko
Okumura, Toshiyuki
Ishikawa, Hitoshi
Sakurai, Hideyuki
Kuwano, Hiroyuki
author_sort Miyazaki, Tatsuya
collection PubMed
description A 50-year-old man who presented with a fever and epigastralgia was diagnosed to have esophageal carcinoma which was identified as poorly differentiated adenocarcinoma producing alpha-fetoprotein (AFP) with Barrett's esophagus. Computed tomography revealed multiple liver metastases and lymph node metastases surrounding the stomach. We first performed chemotherapy for the systemic lesions and proton beam therapy for the local control of lesions without complete remission and we were able to successfully control the frequently recurring lesions by proton beam therapy, cryotherapy and chemotherapy. A complete response has been maintained for 16 months and the overall survival time is 4 years and 2 months. Proton beam therapy for primary esophageal cancer and metastatic lesions was thus found to be an effective therapeutic option for such cases.
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spelling pubmed-61481792018-09-25 Multimodality Therapy Including Proton Beam Therapy for AFP Producing Esophageal Cancer with Multiple Liver Metastases Miyazaki, Tatsuya Sohda, Makoto Sakai, Makoto Kumakura, Yuji Yoshida, Tomonori Kuriyama, Kengo Yokobori, Takehiko Miyazaki, Masaya Hirato, Junko Okumura, Toshiyuki Ishikawa, Hitoshi Sakurai, Hideyuki Kuwano, Hiroyuki Intern Med Case Report A 50-year-old man who presented with a fever and epigastralgia was diagnosed to have esophageal carcinoma which was identified as poorly differentiated adenocarcinoma producing alpha-fetoprotein (AFP) with Barrett's esophagus. Computed tomography revealed multiple liver metastases and lymph node metastases surrounding the stomach. We first performed chemotherapy for the systemic lesions and proton beam therapy for the local control of lesions without complete remission and we were able to successfully control the frequently recurring lesions by proton beam therapy, cryotherapy and chemotherapy. A complete response has been maintained for 16 months and the overall survival time is 4 years and 2 months. Proton beam therapy for primary esophageal cancer and metastatic lesions was thus found to be an effective therapeutic option for such cases. The Japanese Society of Internal Medicine 2018-03-30 2018-08-15 /pmc/articles/PMC6148179/ /pubmed/29607947 http://dx.doi.org/10.2169/internalmedicine.0270-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Miyazaki, Tatsuya
Sohda, Makoto
Sakai, Makoto
Kumakura, Yuji
Yoshida, Tomonori
Kuriyama, Kengo
Yokobori, Takehiko
Miyazaki, Masaya
Hirato, Junko
Okumura, Toshiyuki
Ishikawa, Hitoshi
Sakurai, Hideyuki
Kuwano, Hiroyuki
Multimodality Therapy Including Proton Beam Therapy for AFP Producing Esophageal Cancer with Multiple Liver Metastases
title Multimodality Therapy Including Proton Beam Therapy for AFP Producing Esophageal Cancer with Multiple Liver Metastases
title_full Multimodality Therapy Including Proton Beam Therapy for AFP Producing Esophageal Cancer with Multiple Liver Metastases
title_fullStr Multimodality Therapy Including Proton Beam Therapy for AFP Producing Esophageal Cancer with Multiple Liver Metastases
title_full_unstemmed Multimodality Therapy Including Proton Beam Therapy for AFP Producing Esophageal Cancer with Multiple Liver Metastases
title_short Multimodality Therapy Including Proton Beam Therapy for AFP Producing Esophageal Cancer with Multiple Liver Metastases
title_sort multimodality therapy including proton beam therapy for afp producing esophageal cancer with multiple liver metastases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148179/
https://www.ncbi.nlm.nih.gov/pubmed/29607947
http://dx.doi.org/10.2169/internalmedicine.0270-17
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