Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency

Kidney proximal tubular cells (PTCs) are highly specialized for ultrafiltrate reabsorption and serve as paradigm of apical epithelial differentiation. Vps34/PI3-kinase type III (PI3KC3) regulates endosomal dynamics, macroautophagy and lysosomal function. However, its in vivo role in PTCs has not bee...

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Detalles Bibliográficos
Autores principales: Grieco, Giuseppina, Janssens, Virginie, Gaide Chevronnay, Héloïse P., N’Kuli, Francisca, Van Der Smissen, Patrick, Wang, Tongsong, Shan, Jingdong, Vainio, Seppo, Bilanges, Benoit, Jouret, François, Vanhaesebroeck, Bart, Pierreux, Christophe E., Courtoy, Pierre J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148293/
https://www.ncbi.nlm.nih.gov/pubmed/30237523
http://dx.doi.org/10.1038/s41598-018-32389-z

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