Cargando…
Structure–Activity Relationship and Prediction of the Electron‐Transfer Potential of the Xanthones Series
The structure–activity relationships of 31 xanthones were analyzed by using the ferric reducing antioxidant power (FRAP) assay to determine their electron‐transfer (ET) potential. It was proven that the ET potential of xanthones was dominated by four moieties (i.e. hydroquinone moiety, 5,6‐catechol...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148407/ https://www.ncbi.nlm.nih.gov/pubmed/30258745 http://dx.doi.org/10.1002/open.201800108 |
_version_ | 1783356739440082944 |
---|---|
author | Li, Xican Jiang, Qian Chen, Ban Luo, Xiaoling Chen, Dongfeng |
author_facet | Li, Xican Jiang, Qian Chen, Ban Luo, Xiaoling Chen, Dongfeng |
author_sort | Li, Xican |
collection | PubMed |
description | The structure–activity relationships of 31 xanthones were analyzed by using the ferric reducing antioxidant power (FRAP) assay to determine their electron‐transfer (ET) potential. It was proven that the ET potential of xanthones was dominated by four moieties (i.e. hydroquinone moiety, 5,6‐catechol moiety, 6,7‐catechol moiety, and 7,8‐catechol moiety) and was only slightly affected by other structural features, including a single phenolic OH group, the resorcinol moiety, the transannular dihydroxy moiety, a methoxy group, a sugar residue, an isoprenyl group, a cyclized isoprenyl group, and an isopentanol group. The results could be used to predict the ET potentials of other antioxidant xanthones. |
format | Online Article Text |
id | pubmed-6148407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61484072018-09-26 Structure–Activity Relationship and Prediction of the Electron‐Transfer Potential of the Xanthones Series Li, Xican Jiang, Qian Chen, Ban Luo, Xiaoling Chen, Dongfeng ChemistryOpen Full Papers The structure–activity relationships of 31 xanthones were analyzed by using the ferric reducing antioxidant power (FRAP) assay to determine their electron‐transfer (ET) potential. It was proven that the ET potential of xanthones was dominated by four moieties (i.e. hydroquinone moiety, 5,6‐catechol moiety, 6,7‐catechol moiety, and 7,8‐catechol moiety) and was only slightly affected by other structural features, including a single phenolic OH group, the resorcinol moiety, the transannular dihydroxy moiety, a methoxy group, a sugar residue, an isoprenyl group, a cyclized isoprenyl group, and an isopentanol group. The results could be used to predict the ET potentials of other antioxidant xanthones. John Wiley and Sons Inc. 2018-09-21 /pmc/articles/PMC6148407/ /pubmed/30258745 http://dx.doi.org/10.1002/open.201800108 Text en © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Full Papers Li, Xican Jiang, Qian Chen, Ban Luo, Xiaoling Chen, Dongfeng Structure–Activity Relationship and Prediction of the Electron‐Transfer Potential of the Xanthones Series |
title | Structure–Activity Relationship and Prediction of the Electron‐Transfer Potential of the Xanthones Series |
title_full | Structure–Activity Relationship and Prediction of the Electron‐Transfer Potential of the Xanthones Series |
title_fullStr | Structure–Activity Relationship and Prediction of the Electron‐Transfer Potential of the Xanthones Series |
title_full_unstemmed | Structure–Activity Relationship and Prediction of the Electron‐Transfer Potential of the Xanthones Series |
title_short | Structure–Activity Relationship and Prediction of the Electron‐Transfer Potential of the Xanthones Series |
title_sort | structure–activity relationship and prediction of the electron‐transfer potential of the xanthones series |
topic | Full Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148407/ https://www.ncbi.nlm.nih.gov/pubmed/30258745 http://dx.doi.org/10.1002/open.201800108 |
work_keys_str_mv | AT lixican structureactivityrelationshipandpredictionoftheelectrontransferpotentialofthexanthonesseries AT jiangqian structureactivityrelationshipandpredictionoftheelectrontransferpotentialofthexanthonesseries AT chenban structureactivityrelationshipandpredictionoftheelectrontransferpotentialofthexanthonesseries AT luoxiaoling structureactivityrelationshipandpredictionoftheelectrontransferpotentialofthexanthonesseries AT chendongfeng structureactivityrelationshipandpredictionoftheelectrontransferpotentialofthexanthonesseries |