Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia

The role of Hedgehog signaling in normal and malignant T-cell development is controversial. Recently, Hedgehog pathway mutations have been described in T-ALL, but whether mutational activation of Hedgehog signaling drives T-cell transformation is unknown, hindering the rationale for therapeutic inte...

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Detalles Bibliográficos
Autores principales: Burns, Melissa A., Liao, Zi Wei, Yamagata, Natsuko, Pouliot, Gayle P., Stevenson, Kristen E., Neuberg, Donna S., Thorner, Aaron R., Ducar, Matthew, Silverman, Emily A., Hunger, Stephen P., Loh, Mignon L., Winter, Stuart S., Dunsmore, Kimberly P., Wood, Brent, Devidas, Meenakshi, Harris, Marian H., Silverman, Lewis B., Sallan, Stephen E., Gutierrez, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148437/
https://www.ncbi.nlm.nih.gov/pubmed/29654263
http://dx.doi.org/10.1038/s41375-018-0097-x

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