The role of miR-106p-5p in cervical cancer: from expression to molecular mechanism

This study aims to investigate the role of miR-106b-5p in cervical cancer by performing a comprehensive analysis on its expression and identifying its putative molecular targets and pathways based on The Cancer Genome Atlas (TCGA) dataset, Gene Expression Omnibus (GEO) dataset, and literature review...

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Autores principales: Yi, Yuexiong, Liu, Yanyan, Wu, Wanrong, Wu, Kejia, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148547/
https://www.ncbi.nlm.nih.gov/pubmed/30275981
http://dx.doi.org/10.1038/s41420-018-0096-8
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author Yi, Yuexiong
Liu, Yanyan
Wu, Wanrong
Wu, Kejia
Zhang, Wei
author_facet Yi, Yuexiong
Liu, Yanyan
Wu, Wanrong
Wu, Kejia
Zhang, Wei
author_sort Yi, Yuexiong
collection PubMed
description This study aims to investigate the role of miR-106b-5p in cervical cancer by performing a comprehensive analysis on its expression and identifying its putative molecular targets and pathways based on The Cancer Genome Atlas (TCGA) dataset, Gene Expression Omnibus (GEO) dataset, and literature review. Significant upregulation of miR-106b-5p in cervical cancer is confirmed by meta-analysis with the data from TCGA, GEO, and literature. Moreover, the expression of miR-106b-5p is significantly correlated with the number of metastatic lymph nodes. Our bioinformatics analyses show that miR-106b could promote cervical cancer progression by modulating the expression of GSK3B, VEGFA, and PTK2 genes. Importantly, these three genes play a crucial role in PI3K-Akt signaling, focal adhesion, and cancer. Both the expression of miR-106b-5p and key genes are upregulated in cervical cancer. Several explanations could be implemented for this upregulation. However, the specific mechanism needs to be investigated further.
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spelling pubmed-61485472018-10-01 The role of miR-106p-5p in cervical cancer: from expression to molecular mechanism Yi, Yuexiong Liu, Yanyan Wu, Wanrong Wu, Kejia Zhang, Wei Cell Death Discov Article This study aims to investigate the role of miR-106b-5p in cervical cancer by performing a comprehensive analysis on its expression and identifying its putative molecular targets and pathways based on The Cancer Genome Atlas (TCGA) dataset, Gene Expression Omnibus (GEO) dataset, and literature review. Significant upregulation of miR-106b-5p in cervical cancer is confirmed by meta-analysis with the data from TCGA, GEO, and literature. Moreover, the expression of miR-106b-5p is significantly correlated with the number of metastatic lymph nodes. Our bioinformatics analyses show that miR-106b could promote cervical cancer progression by modulating the expression of GSK3B, VEGFA, and PTK2 genes. Importantly, these three genes play a crucial role in PI3K-Akt signaling, focal adhesion, and cancer. Both the expression of miR-106b-5p and key genes are upregulated in cervical cancer. Several explanations could be implemented for this upregulation. However, the specific mechanism needs to be investigated further. Nature Publishing Group UK 2018-09-20 /pmc/articles/PMC6148547/ /pubmed/30275981 http://dx.doi.org/10.1038/s41420-018-0096-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yi, Yuexiong
Liu, Yanyan
Wu, Wanrong
Wu, Kejia
Zhang, Wei
The role of miR-106p-5p in cervical cancer: from expression to molecular mechanism
title The role of miR-106p-5p in cervical cancer: from expression to molecular mechanism
title_full The role of miR-106p-5p in cervical cancer: from expression to molecular mechanism
title_fullStr The role of miR-106p-5p in cervical cancer: from expression to molecular mechanism
title_full_unstemmed The role of miR-106p-5p in cervical cancer: from expression to molecular mechanism
title_short The role of miR-106p-5p in cervical cancer: from expression to molecular mechanism
title_sort role of mir-106p-5p in cervical cancer: from expression to molecular mechanism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148547/
https://www.ncbi.nlm.nih.gov/pubmed/30275981
http://dx.doi.org/10.1038/s41420-018-0096-8
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