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The impact of helicobacter pylori eradication on platelet counts of adult patients with idiopathic thrombocytopenic purpura
BACKGROUND: Idiopathic (immune) thrombocytopenic purpura (ITP) is an acquired disorder characterized by autoantibodies against platelet membrane antigens. Several studies found an association between Helicobacter Pylori infection and the incidence of ITP. So far, It is still unclear whether H. pylor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148778/ https://www.ncbi.nlm.nih.gov/pubmed/30250741 http://dx.doi.org/10.1186/s12878-018-0119-y |
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author | Aljarad, Sara Alhamid, Ahmad Tarabishi, Ahmad Sankari Suliman, Ameen Aljarad, Ziad |
author_facet | Aljarad, Sara Alhamid, Ahmad Tarabishi, Ahmad Sankari Suliman, Ameen Aljarad, Ziad |
author_sort | Aljarad, Sara |
collection | PubMed |
description | BACKGROUND: Idiopathic (immune) thrombocytopenic purpura (ITP) is an acquired disorder characterized by autoantibodies against platelet membrane antigens. Several studies found an association between Helicobacter Pylori infection and the incidence of ITP. So far, It is still unclear whether H. pylori eradication will increase platelet counts in adult ITP patients. We conduct this study to investigate platelet recovery in ITP patients after H. pylori eradication. METHODS: This is a prospective study. The diagnostic criterion for Idiopathic thrombocytopenic purpura is: isolated thrombocytopenia, with no evidence of any underlying causes like drugs, TTP, SLE, hepatitis, HIV,CLL and… etc. We examined blood smears of all patients. We have diagnosed Helicobacter pylori infection by histological examination of several biopsies obtained from stomach and duodenum by esophagogastroduodenoscopy (EGD). If EGD was not applicable due to patient’s poor situation or platelet count, H.pylori infection was diagnosed by the positivity of serum antibodies or respiratory urease test. We treated infected patients with triple therapy (omeprazole 40 mg once daily, amoxicillin 1000 mg twice daily and clarithromycin 500 mg twice daily) for 14 days. Uninfected patients did not receive any treatment. We did platelet quantification at the beginning of the study, at the end of the first month, at the end of the third month and at the end of the sixth month. RESULTS: This study involved 50 patients with chronic ITP, 29 males (58%) and 21 females (42%). Participants ages range between18 and 51 years (mean age = 28.60 years). We diagnosed H. pylori in 36 patients (72%), who were treated with triple therapy. At the end of the sixth month, 10 of them (27.77%) showed complete response, and 18 of them (50%) showed partial response. The 14 uninfected patients, who did not receive any treatment, did not show neither complete nor partial response. Patient sex and age were not associated with achieving response, while baseline platelet count and H.pylori infection did. CONCLUSION: Helicobacter pylori eradication significantly increases platelet counts in adult ITP patients. |
format | Online Article Text |
id | pubmed-6148778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61487782018-09-24 The impact of helicobacter pylori eradication on platelet counts of adult patients with idiopathic thrombocytopenic purpura Aljarad, Sara Alhamid, Ahmad Tarabishi, Ahmad Sankari Suliman, Ameen Aljarad, Ziad BMC Hematol Research Article BACKGROUND: Idiopathic (immune) thrombocytopenic purpura (ITP) is an acquired disorder characterized by autoantibodies against platelet membrane antigens. Several studies found an association between Helicobacter Pylori infection and the incidence of ITP. So far, It is still unclear whether H. pylori eradication will increase platelet counts in adult ITP patients. We conduct this study to investigate platelet recovery in ITP patients after H. pylori eradication. METHODS: This is a prospective study. The diagnostic criterion for Idiopathic thrombocytopenic purpura is: isolated thrombocytopenia, with no evidence of any underlying causes like drugs, TTP, SLE, hepatitis, HIV,CLL and… etc. We examined blood smears of all patients. We have diagnosed Helicobacter pylori infection by histological examination of several biopsies obtained from stomach and duodenum by esophagogastroduodenoscopy (EGD). If EGD was not applicable due to patient’s poor situation or platelet count, H.pylori infection was diagnosed by the positivity of serum antibodies or respiratory urease test. We treated infected patients with triple therapy (omeprazole 40 mg once daily, amoxicillin 1000 mg twice daily and clarithromycin 500 mg twice daily) for 14 days. Uninfected patients did not receive any treatment. We did platelet quantification at the beginning of the study, at the end of the first month, at the end of the third month and at the end of the sixth month. RESULTS: This study involved 50 patients with chronic ITP, 29 males (58%) and 21 females (42%). Participants ages range between18 and 51 years (mean age = 28.60 years). We diagnosed H. pylori in 36 patients (72%), who were treated with triple therapy. At the end of the sixth month, 10 of them (27.77%) showed complete response, and 18 of them (50%) showed partial response. The 14 uninfected patients, who did not receive any treatment, did not show neither complete nor partial response. Patient sex and age were not associated with achieving response, while baseline platelet count and H.pylori infection did. CONCLUSION: Helicobacter pylori eradication significantly increases platelet counts in adult ITP patients. BioMed Central 2018-09-20 /pmc/articles/PMC6148778/ /pubmed/30250741 http://dx.doi.org/10.1186/s12878-018-0119-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Aljarad, Sara Alhamid, Ahmad Tarabishi, Ahmad Sankari Suliman, Ameen Aljarad, Ziad The impact of helicobacter pylori eradication on platelet counts of adult patients with idiopathic thrombocytopenic purpura |
title | The impact of helicobacter pylori eradication on platelet counts of adult patients with idiopathic thrombocytopenic purpura |
title_full | The impact of helicobacter pylori eradication on platelet counts of adult patients with idiopathic thrombocytopenic purpura |
title_fullStr | The impact of helicobacter pylori eradication on platelet counts of adult patients with idiopathic thrombocytopenic purpura |
title_full_unstemmed | The impact of helicobacter pylori eradication on platelet counts of adult patients with idiopathic thrombocytopenic purpura |
title_short | The impact of helicobacter pylori eradication on platelet counts of adult patients with idiopathic thrombocytopenic purpura |
title_sort | impact of helicobacter pylori eradication on platelet counts of adult patients with idiopathic thrombocytopenic purpura |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148778/ https://www.ncbi.nlm.nih.gov/pubmed/30250741 http://dx.doi.org/10.1186/s12878-018-0119-y |
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