Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA

BACKGROUND: A recent study found that CD177 served as a receptor of membrane-bound proteinase-3 (mPR3) in a subset of neutrophils. Furthermore, CD177 has been identified as a high-affinity heterophilic binding partner for the endothelial cell platelet endothelial cell adhesion molecule-1 (PECAM-1)....

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Detalles Bibliográficos
Autores principales: Deng, Hui, Hu, Nan, Wang, Chen, Chen, Min, Zhao, Ming-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148996/
https://www.ncbi.nlm.nih.gov/pubmed/30236159
http://dx.doi.org/10.1186/s13075-018-1710-0

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