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A Novel Strategy for Quantitative Analysis of Major Ginsenosides in Panacis Japonici Rhizoma with a Standardized Reference Fraction
Panacis Japonici Rhizoma (Zhu-Jie-Shen in Chinese), the root of P. japonicus C.A. Mey., is commonly used in traditional Chinese Medicine. Saponins are the major bioactive compounds in this herb. The similarity of polarity and structure of the natural products in herb caused the difficulty of purific...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149681/ https://www.ncbi.nlm.nih.gov/pubmed/29186881 http://dx.doi.org/10.3390/molecules22122067 |
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author | Meng, Fan-Cheng Wu, Qiu-Shuang Wang, Ruibing Li, Shao-Ping Lin, Li-Gen Chen, Ping Zhang, Qing-Wen |
author_facet | Meng, Fan-Cheng Wu, Qiu-Shuang Wang, Ruibing Li, Shao-Ping Lin, Li-Gen Chen, Ping Zhang, Qing-Wen |
author_sort | Meng, Fan-Cheng |
collection | PubMed |
description | Panacis Japonici Rhizoma (Zhu-Jie-Shen in Chinese), the root of P. japonicus C.A. Mey., is commonly used in traditional Chinese Medicine. Saponins are the major bioactive compounds in this herb. The similarity of polarity and structure of the natural products in herb caused the difficulty of purification and resulted in the shortage and high cost of the reference compounds, which has greatly hindered efforts toward quantification in quality control. A novel strategy using a standardized reference fraction for qualification of the major saponins in Panacis Japonici Rhizoma was proposed to easily and effectively control the quality of PJR. The strategy is feasible and reliable, and the methodology of the developed approach is also validated. The standardized reference fraction was used for quantification, which might solve the shortage of the pure reference compounds in the quality control of herbal medicines. |
format | Online Article Text |
id | pubmed-6149681 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61496812018-11-13 A Novel Strategy for Quantitative Analysis of Major Ginsenosides in Panacis Japonici Rhizoma with a Standardized Reference Fraction Meng, Fan-Cheng Wu, Qiu-Shuang Wang, Ruibing Li, Shao-Ping Lin, Li-Gen Chen, Ping Zhang, Qing-Wen Molecules Article Panacis Japonici Rhizoma (Zhu-Jie-Shen in Chinese), the root of P. japonicus C.A. Mey., is commonly used in traditional Chinese Medicine. Saponins are the major bioactive compounds in this herb. The similarity of polarity and structure of the natural products in herb caused the difficulty of purification and resulted in the shortage and high cost of the reference compounds, which has greatly hindered efforts toward quantification in quality control. A novel strategy using a standardized reference fraction for qualification of the major saponins in Panacis Japonici Rhizoma was proposed to easily and effectively control the quality of PJR. The strategy is feasible and reliable, and the methodology of the developed approach is also validated. The standardized reference fraction was used for quantification, which might solve the shortage of the pure reference compounds in the quality control of herbal medicines. MDPI 2017-11-27 /pmc/articles/PMC6149681/ /pubmed/29186881 http://dx.doi.org/10.3390/molecules22122067 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Meng, Fan-Cheng Wu, Qiu-Shuang Wang, Ruibing Li, Shao-Ping Lin, Li-Gen Chen, Ping Zhang, Qing-Wen A Novel Strategy for Quantitative Analysis of Major Ginsenosides in Panacis Japonici Rhizoma with a Standardized Reference Fraction |
title | A Novel Strategy for Quantitative Analysis of Major Ginsenosides in Panacis Japonici Rhizoma with a Standardized Reference Fraction |
title_full | A Novel Strategy for Quantitative Analysis of Major Ginsenosides in Panacis Japonici Rhizoma with a Standardized Reference Fraction |
title_fullStr | A Novel Strategy for Quantitative Analysis of Major Ginsenosides in Panacis Japonici Rhizoma with a Standardized Reference Fraction |
title_full_unstemmed | A Novel Strategy for Quantitative Analysis of Major Ginsenosides in Panacis Japonici Rhizoma with a Standardized Reference Fraction |
title_short | A Novel Strategy for Quantitative Analysis of Major Ginsenosides in Panacis Japonici Rhizoma with a Standardized Reference Fraction |
title_sort | novel strategy for quantitative analysis of major ginsenosides in panacis japonici rhizoma with a standardized reference fraction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149681/ https://www.ncbi.nlm.nih.gov/pubmed/29186881 http://dx.doi.org/10.3390/molecules22122067 |
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