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PSPC1 potentiates TGF-β-dependent metastatic dissemination
Metastatic reprogramming toward malignant tumor progression relies on the activation of oncogenic regulators, yet the cellular determinants remain elucidated. Through identification of aberrant prognostic cancer genes, we identified paraspeckle component 1 (PSPC1) functions as a master activator of...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149759/ https://www.ncbi.nlm.nih.gov/pubmed/30250921 http://dx.doi.org/10.1080/23723556.2018.1472058 |
| _version_ | 1783356862529273856 |
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| author | Yeh, Hsi-Wen Jou, Yuh-Shan |
| author_facet | Yeh, Hsi-Wen Jou, Yuh-Shan |
| author_sort | Yeh, Hsi-Wen |
| collection | PubMed |
| description | Metastatic reprogramming toward malignant tumor progression relies on the activation of oncogenic regulators, yet the cellular determinants remain elucidated. Through identification of aberrant prognostic cancer genes, we identified paraspeckle component 1 (PSPC1) functions as a master activator of metastatic reprogramming by activating epithelial-to-mesenchymal transition (EMT), stemness and TGF-β1 pro-metastatic switch. |
| format | Online Article Text |
| id | pubmed-6149759 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Taylor & Francis |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-61497592019-08-01 PSPC1 potentiates TGF-β-dependent metastatic dissemination Yeh, Hsi-Wen Jou, Yuh-Shan Mol Cell Oncol Author's Views Metastatic reprogramming toward malignant tumor progression relies on the activation of oncogenic regulators, yet the cellular determinants remain elucidated. Through identification of aberrant prognostic cancer genes, we identified paraspeckle component 1 (PSPC1) functions as a master activator of metastatic reprogramming by activating epithelial-to-mesenchymal transition (EMT), stemness and TGF-β1 pro-metastatic switch. Taylor & Francis 2018-08-01 /pmc/articles/PMC6149759/ /pubmed/30250921 http://dx.doi.org/10.1080/23723556.2018.1472058 Text en © 2018 The Author(s). Published by Taylor & Francis. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
| spellingShingle | Author's Views Yeh, Hsi-Wen Jou, Yuh-Shan PSPC1 potentiates TGF-β-dependent metastatic dissemination |
| title | PSPC1 potentiates TGF-β-dependent metastatic dissemination |
| title_full | PSPC1 potentiates TGF-β-dependent metastatic dissemination |
| title_fullStr | PSPC1 potentiates TGF-β-dependent metastatic dissemination |
| title_full_unstemmed | PSPC1 potentiates TGF-β-dependent metastatic dissemination |
| title_short | PSPC1 potentiates TGF-β-dependent metastatic dissemination |
| title_sort | pspc1 potentiates tgf-β-dependent metastatic dissemination |
| topic | Author's Views |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149759/ https://www.ncbi.nlm.nih.gov/pubmed/30250921 http://dx.doi.org/10.1080/23723556.2018.1472058 |
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