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In Vivo Activity of LCB 01-0699, a Prodrug of LCB 01-0648, against Staphylococcus aureus
LCB01-0648 is a novel oxazolidinone compound that shows potent antibacterial activities against most Gram-positive cocci, including the multi-drug resistant Staphylococcus aureus. In this study, in vivo activity of LCB01-0699, a LCB01-0648 prodrug, against S. aureus was evaluated in comparison with...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149760/ https://www.ncbi.nlm.nih.gov/pubmed/29186032 http://dx.doi.org/10.3390/molecules22122096 |
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author | Oh, Sang-Hun Park, Hee-Soo Lee, Jun-Hyung Baek, Sung-Yun Chae, Sang-Eun Oh, Kyuman Cho, Young Lag Kwak, Jin-Hwan |
author_facet | Oh, Sang-Hun Park, Hee-Soo Lee, Jun-Hyung Baek, Sung-Yun Chae, Sang-Eun Oh, Kyuman Cho, Young Lag Kwak, Jin-Hwan |
author_sort | Oh, Sang-Hun |
collection | PubMed |
description | LCB01-0648 is a novel oxazolidinone compound that shows potent antibacterial activities against most Gram-positive cocci, including the multi-drug resistant Staphylococcus aureus. In this study, in vivo activity of LCB01-0699, a LCB01-0648 prodrug, against S. aureus was evaluated in comparison with that of Linezolid. The results of the systemic infection study demonstrated that LCB01-0699 was more potent than Linezolid against methicillin-susceptible and -resistant S. aureus strains. The in vivo efficacy of LCB01-0699 against methicillin-susceptible and -resistant S. aureus strains in a skin infection model showed more potent activity than Linezolid. LCB01-0699 shows potent in vivo activity against methicillin-susceptible and -resistant S. aureus strains, suggesting that LCB01-0699 would be a novel candidate for the treatment of these infectious diseases caused by S. aureus. |
format | Online Article Text |
id | pubmed-6149760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61497602018-11-13 In Vivo Activity of LCB 01-0699, a Prodrug of LCB 01-0648, against Staphylococcus aureus Oh, Sang-Hun Park, Hee-Soo Lee, Jun-Hyung Baek, Sung-Yun Chae, Sang-Eun Oh, Kyuman Cho, Young Lag Kwak, Jin-Hwan Molecules Article LCB01-0648 is a novel oxazolidinone compound that shows potent antibacterial activities against most Gram-positive cocci, including the multi-drug resistant Staphylococcus aureus. In this study, in vivo activity of LCB01-0699, a LCB01-0648 prodrug, against S. aureus was evaluated in comparison with that of Linezolid. The results of the systemic infection study demonstrated that LCB01-0699 was more potent than Linezolid against methicillin-susceptible and -resistant S. aureus strains. The in vivo efficacy of LCB01-0699 against methicillin-susceptible and -resistant S. aureus strains in a skin infection model showed more potent activity than Linezolid. LCB01-0699 shows potent in vivo activity against methicillin-susceptible and -resistant S. aureus strains, suggesting that LCB01-0699 would be a novel candidate for the treatment of these infectious diseases caused by S. aureus. MDPI 2017-11-29 /pmc/articles/PMC6149760/ /pubmed/29186032 http://dx.doi.org/10.3390/molecules22122096 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Oh, Sang-Hun Park, Hee-Soo Lee, Jun-Hyung Baek, Sung-Yun Chae, Sang-Eun Oh, Kyuman Cho, Young Lag Kwak, Jin-Hwan In Vivo Activity of LCB 01-0699, a Prodrug of LCB 01-0648, against Staphylococcus aureus |
title | In Vivo Activity of LCB 01-0699, a Prodrug of LCB 01-0648, against Staphylococcus aureus |
title_full | In Vivo Activity of LCB 01-0699, a Prodrug of LCB 01-0648, against Staphylococcus aureus |
title_fullStr | In Vivo Activity of LCB 01-0699, a Prodrug of LCB 01-0648, against Staphylococcus aureus |
title_full_unstemmed | In Vivo Activity of LCB 01-0699, a Prodrug of LCB 01-0648, against Staphylococcus aureus |
title_short | In Vivo Activity of LCB 01-0699, a Prodrug of LCB 01-0648, against Staphylococcus aureus |
title_sort | in vivo activity of lcb 01-0699, a prodrug of lcb 01-0648, against staphylococcus aureus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149760/ https://www.ncbi.nlm.nih.gov/pubmed/29186032 http://dx.doi.org/10.3390/molecules22122096 |
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