LPCAT2 controls chemoresistance in colorectal cancer

Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine...

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Detalles Bibliográficos
Autores principales: Cotte, Alexia Karen, Aires, Virginie, Ghiringhelli, François, Delmas, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149788/
https://www.ncbi.nlm.nih.gov/pubmed/30250902
http://dx.doi.org/10.1080/23723556.2018.1448245
Descripción
Sumario:Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine acyltransferase 2 (LPCAT2) enzyme expression. We also showed that chemotherapy-induced LD accumulation counteracts intrinsic and extrinsic cancer cell death activation.

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