LPCAT2 controls chemoresistance in colorectal cancer

Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine...

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Detalles Bibliográficos
Autores principales: Cotte, Alexia Karen, Aires, Virginie, Ghiringhelli, François, Delmas, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149788/
https://www.ncbi.nlm.nih.gov/pubmed/30250902
http://dx.doi.org/10.1080/23723556.2018.1448245
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author Cotte, Alexia Karen
Aires, Virginie
Ghiringhelli, François
Delmas, Dominique
author_facet Cotte, Alexia Karen
Aires, Virginie
Ghiringhelli, François
Delmas, Dominique
author_sort Cotte, Alexia Karen
collection PubMed
description Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine acyltransferase 2 (LPCAT2) enzyme expression. We also showed that chemotherapy-induced LD accumulation counteracts intrinsic and extrinsic cancer cell death activation.
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spelling pubmed-61497882019-04-11 LPCAT2 controls chemoresistance in colorectal cancer Cotte, Alexia Karen Aires, Virginie Ghiringhelli, François Delmas, Dominique Mol Cell Oncol Author's Views Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine acyltransferase 2 (LPCAT2) enzyme expression. We also showed that chemotherapy-induced LD accumulation counteracts intrinsic and extrinsic cancer cell death activation. Taylor & Francis 2018-04-11 /pmc/articles/PMC6149788/ /pubmed/30250902 http://dx.doi.org/10.1080/23723556.2018.1448245 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Cotte, Alexia Karen
Aires, Virginie
Ghiringhelli, François
Delmas, Dominique
LPCAT2 controls chemoresistance in colorectal cancer
title LPCAT2 controls chemoresistance in colorectal cancer
title_full LPCAT2 controls chemoresistance in colorectal cancer
title_fullStr LPCAT2 controls chemoresistance in colorectal cancer
title_full_unstemmed LPCAT2 controls chemoresistance in colorectal cancer
title_short LPCAT2 controls chemoresistance in colorectal cancer
title_sort lpcat2 controls chemoresistance in colorectal cancer
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149788/
https://www.ncbi.nlm.nih.gov/pubmed/30250902
http://dx.doi.org/10.1080/23723556.2018.1448245
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AT delmasdominique lpcat2controlschemoresistanceincolorectalcancer

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