Mediating the death of dormant tumor cells

How immunological cues trigger cancer cell-intrinsic signaling pathways for their entering dormancy remains an enigma. In out recent studies, we found that IFN-β induces tumor-repopulating cells (TRC) into dormancy by activating Indoleamine-pyrrole 2,3-dioxygenase (IDO)-Kynurenine-aryl hydrocarbon r...

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Detalles Bibliográficos
Autores principales: Liu, Yuying, Lv, Jiadi, Huang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149803/
https://www.ncbi.nlm.nih.gov/pubmed/30250912
http://dx.doi.org/10.1080/23723556.2018.1458013
Descripción
Sumario:How immunological cues trigger cancer cell-intrinsic signaling pathways for their entering dormancy remains an enigma. In out recent studies, we found that IFN-β induces tumor-repopulating cells (TRC) into dormancy by activating Indoleamine-pyrrole 2,3-dioxygenase (IDO)-Kynurenine-aryl hydrocarbon receptor (AhR)-cyclin-dependent kinase inhibitor 1B (p27) pathway, while blocking this pathway leads dormant TRCs to apoptosis by switching to STAT3-cellular tumor antigen p53 (p53) pathway.

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