Mediating the death of dormant tumor cells

How immunological cues trigger cancer cell-intrinsic signaling pathways for their entering dormancy remains an enigma. In out recent studies, we found that IFN-β induces tumor-repopulating cells (TRC) into dormancy by activating Indoleamine-pyrrole 2,3-dioxygenase (IDO)-Kynurenine-aryl hydrocarbon r...

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Detalles Bibliográficos
Autores principales: Liu, Yuying, Lv, Jiadi, Huang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149803/
https://www.ncbi.nlm.nih.gov/pubmed/30250912
http://dx.doi.org/10.1080/23723556.2018.1458013
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author Liu, Yuying
Lv, Jiadi
Huang, Bo
author_facet Liu, Yuying
Lv, Jiadi
Huang, Bo
author_sort Liu, Yuying
collection PubMed
description How immunological cues trigger cancer cell-intrinsic signaling pathways for their entering dormancy remains an enigma. In out recent studies, we found that IFN-β induces tumor-repopulating cells (TRC) into dormancy by activating Indoleamine-pyrrole 2,3-dioxygenase (IDO)-Kynurenine-aryl hydrocarbon receptor (AhR)-cyclin-dependent kinase inhibitor 1B (p27) pathway, while blocking this pathway leads dormant TRCs to apoptosis by switching to STAT3-cellular tumor antigen p53 (p53) pathway.
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spelling pubmed-61498032019-08-06 Mediating the death of dormant tumor cells Liu, Yuying Lv, Jiadi Huang, Bo Mol Cell Oncol Commentary How immunological cues trigger cancer cell-intrinsic signaling pathways for their entering dormancy remains an enigma. In out recent studies, we found that IFN-β induces tumor-repopulating cells (TRC) into dormancy by activating Indoleamine-pyrrole 2,3-dioxygenase (IDO)-Kynurenine-aryl hydrocarbon receptor (AhR)-cyclin-dependent kinase inhibitor 1B (p27) pathway, while blocking this pathway leads dormant TRCs to apoptosis by switching to STAT3-cellular tumor antigen p53 (p53) pathway. Taylor & Francis 2018-08-06 /pmc/articles/PMC6149803/ /pubmed/30250912 http://dx.doi.org/10.1080/23723556.2018.1458013 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Liu, Yuying
Lv, Jiadi
Huang, Bo
Mediating the death of dormant tumor cells
title Mediating the death of dormant tumor cells
title_full Mediating the death of dormant tumor cells
title_fullStr Mediating the death of dormant tumor cells
title_full_unstemmed Mediating the death of dormant tumor cells
title_short Mediating the death of dormant tumor cells
title_sort mediating the death of dormant tumor cells
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149803/
https://www.ncbi.nlm.nih.gov/pubmed/30250912
http://dx.doi.org/10.1080/23723556.2018.1458013
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