Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer

Studies in single cell transcriptomics have significantly expanded our understanding of tumor biology, including recent analyses in head and neck squamous cell carcinoma. Here, we focus on the role of a partial epithelial-to-mesenchymal (EMT) program in these tumors, with discussion of its dynamics,...

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Autores principales: Puram, Sidharth V., Parikh, Anuraag S., Tirosh, Itay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149805/
https://www.ncbi.nlm.nih.gov/pubmed/30250901
http://dx.doi.org/10.1080/23723556.2018.1448244
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author Puram, Sidharth V.
Parikh, Anuraag S.
Tirosh, Itay
author_facet Puram, Sidharth V.
Parikh, Anuraag S.
Tirosh, Itay
author_sort Puram, Sidharth V.
collection PubMed
description Studies in single cell transcriptomics have significantly expanded our understanding of tumor biology, including recent analyses in head and neck squamous cell carcinoma. Here, we focus on the role of a partial epithelial-to-mesenchymal (EMT) program in these tumors, with discussion of its dynamics, regulation, and implications for diagnostic and therapeutic approaches.
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spelling pubmed-61498052019-03-07 Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer Puram, Sidharth V. Parikh, Anuraag S. Tirosh, Itay Mol Cell Oncol Author's Views Studies in single cell transcriptomics have significantly expanded our understanding of tumor biology, including recent analyses in head and neck squamous cell carcinoma. Here, we focus on the role of a partial epithelial-to-mesenchymal (EMT) program in these tumors, with discussion of its dynamics, regulation, and implications for diagnostic and therapeutic approaches. Taylor & Francis 2018-03-07 /pmc/articles/PMC6149805/ /pubmed/30250901 http://dx.doi.org/10.1080/23723556.2018.1448244 Text en © 2018 Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc-nd/4.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's Views
Puram, Sidharth V.
Parikh, Anuraag S.
Tirosh, Itay
Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer
title Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer
title_full Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer
title_fullStr Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer
title_full_unstemmed Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer
title_short Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer
title_sort single cell rna-seq highlights a role for a partial emt in head and neck cancer
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149805/
https://www.ncbi.nlm.nih.gov/pubmed/30250901
http://dx.doi.org/10.1080/23723556.2018.1448244
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