Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy

Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its mitochondrial targeting and interaction with tumor n...

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Detalles Bibliográficos
Autores principales: Hu, Mengjie, Alitongbieke, Gulimiran, Su, Ying, Zhou, Hu, Zhang, Xiao-kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149810/
https://www.ncbi.nlm.nih.gov/pubmed/30250883
http://dx.doi.org/10.1080/23723556.2017.1327005
Descripción
Sumario:Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its mitochondrial targeting and interaction with tumor necrosis factor receptor-associated factor 2 (TRAF2) and the autophagic adaptor p62/SQSTM1.

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