Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy

Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its mitochondrial targeting and interaction with tumor n...

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Autores principales: Hu, Mengjie, Alitongbieke, Gulimiran, Su, Ying, Zhou, Hu, Zhang, Xiao-kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149810/
https://www.ncbi.nlm.nih.gov/pubmed/30250883
http://dx.doi.org/10.1080/23723556.2017.1327005
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author Hu, Mengjie
Alitongbieke, Gulimiran
Su, Ying
Zhou, Hu
Zhang, Xiao-kun
author_facet Hu, Mengjie
Alitongbieke, Gulimiran
Su, Ying
Zhou, Hu
Zhang, Xiao-kun
author_sort Hu, Mengjie
collection PubMed
description Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its mitochondrial targeting and interaction with tumor necrosis factor receptor-associated factor 2 (TRAF2) and the autophagic adaptor p62/SQSTM1.
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spelling pubmed-61498102019-03-05 Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy Hu, Mengjie Alitongbieke, Gulimiran Su, Ying Zhou, Hu Zhang, Xiao-kun Mol Cell Oncol Author's Views Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its mitochondrial targeting and interaction with tumor necrosis factor receptor-associated factor 2 (TRAF2) and the autophagic adaptor p62/SQSTM1. Taylor & Francis 2018-03-05 /pmc/articles/PMC6149810/ /pubmed/30250883 http://dx.doi.org/10.1080/23723556.2017.1327005 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Hu, Mengjie
Alitongbieke, Gulimiran
Su, Ying
Zhou, Hu
Zhang, Xiao-kun
Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy
title Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy
title_full Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy
title_fullStr Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy
title_full_unstemmed Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy
title_short Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy
title_sort moving nuclear receptor nur77 to damaged mitochondria for clearance by mitophagy
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149810/
https://www.ncbi.nlm.nih.gov/pubmed/30250883
http://dx.doi.org/10.1080/23723556.2017.1327005
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