Cargando…
Therapy-related myeloid neoplasms: clinical perspectives
Therapy-related myeloid neoplasms (t-MNs) are a complication of cytotoxic treatment for primary tumors and autoimmune diseases. t-MNs result from a complex interaction between individual predisposition and exposition to toxic agents. Some different biological and clinical characteristics can be reco...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149829/ https://www.ncbi.nlm.nih.gov/pubmed/30271175 http://dx.doi.org/10.2147/OTT.S101333 |
_version_ | 1783356877697974272 |
---|---|
author | Fianchi, Luana Criscuolo, Marianna Fabiani, Emiliano Falconi, Giulia Maraglino, Alessio Maria Edoardo Voso, Maria Teresa Pagano, Livio |
author_facet | Fianchi, Luana Criscuolo, Marianna Fabiani, Emiliano Falconi, Giulia Maraglino, Alessio Maria Edoardo Voso, Maria Teresa Pagano, Livio |
author_sort | Fianchi, Luana |
collection | PubMed |
description | Therapy-related myeloid neoplasms (t-MNs) are a complication of cytotoxic treatment for primary tumors and autoimmune diseases. t-MNs result from a complex interaction between individual predisposition and exposition to toxic agents. Some different biological and clinical characteristics can be recognized according to the type of anticancer drug. Compared to de novo myeloid neoplasms, prognosis of t-MN is dismal. Age and karyotype are the most important prognostic factors for t-MN, which should be treated with frontline chemotherapy treatments that are appropriate for patients with myelodysplastic syndrome (MDS) and de novo acute myeloid leukemia (AML) with similar disease characteristics. Allogeneic stem cell transplantation should be considered particularly for unfavorable karyotypes and younger patients with aggressive disease. |
format | Online Article Text |
id | pubmed-6149829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-61498292018-09-28 Therapy-related myeloid neoplasms: clinical perspectives Fianchi, Luana Criscuolo, Marianna Fabiani, Emiliano Falconi, Giulia Maraglino, Alessio Maria Edoardo Voso, Maria Teresa Pagano, Livio Onco Targets Ther Review Therapy-related myeloid neoplasms (t-MNs) are a complication of cytotoxic treatment for primary tumors and autoimmune diseases. t-MNs result from a complex interaction between individual predisposition and exposition to toxic agents. Some different biological and clinical characteristics can be recognized according to the type of anticancer drug. Compared to de novo myeloid neoplasms, prognosis of t-MN is dismal. Age and karyotype are the most important prognostic factors for t-MN, which should be treated with frontline chemotherapy treatments that are appropriate for patients with myelodysplastic syndrome (MDS) and de novo acute myeloid leukemia (AML) with similar disease characteristics. Allogeneic stem cell transplantation should be considered particularly for unfavorable karyotypes and younger patients with aggressive disease. Dove Medical Press 2018-09-17 /pmc/articles/PMC6149829/ /pubmed/30271175 http://dx.doi.org/10.2147/OTT.S101333 Text en © 2018 Fianchi et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Fianchi, Luana Criscuolo, Marianna Fabiani, Emiliano Falconi, Giulia Maraglino, Alessio Maria Edoardo Voso, Maria Teresa Pagano, Livio Therapy-related myeloid neoplasms: clinical perspectives |
title | Therapy-related myeloid neoplasms: clinical perspectives |
title_full | Therapy-related myeloid neoplasms: clinical perspectives |
title_fullStr | Therapy-related myeloid neoplasms: clinical perspectives |
title_full_unstemmed | Therapy-related myeloid neoplasms: clinical perspectives |
title_short | Therapy-related myeloid neoplasms: clinical perspectives |
title_sort | therapy-related myeloid neoplasms: clinical perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149829/ https://www.ncbi.nlm.nih.gov/pubmed/30271175 http://dx.doi.org/10.2147/OTT.S101333 |
work_keys_str_mv | AT fianchiluana therapyrelatedmyeloidneoplasmsclinicalperspectives AT criscuolomarianna therapyrelatedmyeloidneoplasmsclinicalperspectives AT fabianiemiliano therapyrelatedmyeloidneoplasmsclinicalperspectives AT falconigiulia therapyrelatedmyeloidneoplasmsclinicalperspectives AT maraglinoalessiomariaedoardo therapyrelatedmyeloidneoplasmsclinicalperspectives AT vosomariateresa therapyrelatedmyeloidneoplasmsclinicalperspectives AT paganolivio therapyrelatedmyeloidneoplasmsclinicalperspectives |