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Therapy-related myeloid neoplasms: clinical perspectives

Therapy-related myeloid neoplasms (t-MNs) are a complication of cytotoxic treatment for primary tumors and autoimmune diseases. t-MNs result from a complex interaction between individual predisposition and exposition to toxic agents. Some different biological and clinical characteristics can be reco...

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Autores principales: Fianchi, Luana, Criscuolo, Marianna, Fabiani, Emiliano, Falconi, Giulia, Maraglino, Alessio Maria Edoardo, Voso, Maria Teresa, Pagano, Livio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149829/
https://www.ncbi.nlm.nih.gov/pubmed/30271175
http://dx.doi.org/10.2147/OTT.S101333
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author Fianchi, Luana
Criscuolo, Marianna
Fabiani, Emiliano
Falconi, Giulia
Maraglino, Alessio Maria Edoardo
Voso, Maria Teresa
Pagano, Livio
author_facet Fianchi, Luana
Criscuolo, Marianna
Fabiani, Emiliano
Falconi, Giulia
Maraglino, Alessio Maria Edoardo
Voso, Maria Teresa
Pagano, Livio
author_sort Fianchi, Luana
collection PubMed
description Therapy-related myeloid neoplasms (t-MNs) are a complication of cytotoxic treatment for primary tumors and autoimmune diseases. t-MNs result from a complex interaction between individual predisposition and exposition to toxic agents. Some different biological and clinical characteristics can be recognized according to the type of anticancer drug. Compared to de novo myeloid neoplasms, prognosis of t-MN is dismal. Age and karyotype are the most important prognostic factors for t-MN, which should be treated with frontline chemotherapy treatments that are appropriate for patients with myelodysplastic syndrome (MDS) and de novo acute myeloid leukemia (AML) with similar disease characteristics. Allogeneic stem cell transplantation should be considered particularly for unfavorable karyotypes and younger patients with aggressive disease.
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spelling pubmed-61498292018-09-28 Therapy-related myeloid neoplasms: clinical perspectives Fianchi, Luana Criscuolo, Marianna Fabiani, Emiliano Falconi, Giulia Maraglino, Alessio Maria Edoardo Voso, Maria Teresa Pagano, Livio Onco Targets Ther Review Therapy-related myeloid neoplasms (t-MNs) are a complication of cytotoxic treatment for primary tumors and autoimmune diseases. t-MNs result from a complex interaction between individual predisposition and exposition to toxic agents. Some different biological and clinical characteristics can be recognized according to the type of anticancer drug. Compared to de novo myeloid neoplasms, prognosis of t-MN is dismal. Age and karyotype are the most important prognostic factors for t-MN, which should be treated with frontline chemotherapy treatments that are appropriate for patients with myelodysplastic syndrome (MDS) and de novo acute myeloid leukemia (AML) with similar disease characteristics. Allogeneic stem cell transplantation should be considered particularly for unfavorable karyotypes and younger patients with aggressive disease. Dove Medical Press 2018-09-17 /pmc/articles/PMC6149829/ /pubmed/30271175 http://dx.doi.org/10.2147/OTT.S101333 Text en © 2018 Fianchi et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Fianchi, Luana
Criscuolo, Marianna
Fabiani, Emiliano
Falconi, Giulia
Maraglino, Alessio Maria Edoardo
Voso, Maria Teresa
Pagano, Livio
Therapy-related myeloid neoplasms: clinical perspectives
title Therapy-related myeloid neoplasms: clinical perspectives
title_full Therapy-related myeloid neoplasms: clinical perspectives
title_fullStr Therapy-related myeloid neoplasms: clinical perspectives
title_full_unstemmed Therapy-related myeloid neoplasms: clinical perspectives
title_short Therapy-related myeloid neoplasms: clinical perspectives
title_sort therapy-related myeloid neoplasms: clinical perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149829/
https://www.ncbi.nlm.nih.gov/pubmed/30271175
http://dx.doi.org/10.2147/OTT.S101333
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