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Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion
BACKGROUND: Tendon adhesion is a serious problem and it affects tendon gliding and joint motion. Although recent studies have yielded promising results in developing anti-adhesion materials, there are still many problems. Polycaprolactone (PCL)-based polyurethane (PU) has good mechanical properties...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149831/ https://www.ncbi.nlm.nih.gov/pubmed/30271142 http://dx.doi.org/10.2147/IJN.S169825 |
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author | Hsu, Shan-hui Dai, Lien-Guo Hung, Yu-Min Dai, Niann-Tzyy |
author_facet | Hsu, Shan-hui Dai, Lien-Guo Hung, Yu-Min Dai, Niann-Tzyy |
author_sort | Hsu, Shan-hui |
collection | PubMed |
description | BACKGROUND: Tendon adhesion is a serious problem and it affects tendon gliding and joint motion. Although recent studies have yielded promising results in developing anti-adhesion materials, there are still many problems. Polycaprolactone (PCL)-based polyurethane (PU) has good mechanical properties and biocompatibility, and it has a potential in anti-adhesion applications. MATERIALS AND METHODS: In this study, a series of waterborne biodegradable polyurethane (WBPU) films with different ratios of ionic groups were synthesized. In order to select an effective anti-adhesion film, the WBPU films were cast and characterized for physicochemical properties and biocompatibility. RESULTS: All WBPU films were non-cytotoxic in the cell viability test and had suitable physicochemical and mechanical properties based on the measurement of zeta potential, water contact angle, mechanical properties, water absorption, thickness change, and gelatin test. To evaluate the anti-adhesion effect, severely injured tendons of rabbits were sutured with the modified Kessler core suture technique and WBPU films were then wrapped around the tendon. Implantation in rabbits showed that the WBPU film had better anti-adhesion effect than PCL films and the untreated control, and demonstrated no significant difference in the anti-adhesion performance from the commercial product Seprafilm based on gross evaluation, histological analysis, and biomechanical assessment. CONCLUSION: Compared to Seprafilm and PCL applied in the tendon anti-adhesion, WBPU had better mechanical properties, low inflammatory reaction, and a proper degradation interval. |
format | Online Article Text |
id | pubmed-6149831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-61498312018-09-28 Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion Hsu, Shan-hui Dai, Lien-Guo Hung, Yu-Min Dai, Niann-Tzyy Int J Nanomedicine Original Research BACKGROUND: Tendon adhesion is a serious problem and it affects tendon gliding and joint motion. Although recent studies have yielded promising results in developing anti-adhesion materials, there are still many problems. Polycaprolactone (PCL)-based polyurethane (PU) has good mechanical properties and biocompatibility, and it has a potential in anti-adhesion applications. MATERIALS AND METHODS: In this study, a series of waterborne biodegradable polyurethane (WBPU) films with different ratios of ionic groups were synthesized. In order to select an effective anti-adhesion film, the WBPU films were cast and characterized for physicochemical properties and biocompatibility. RESULTS: All WBPU films were non-cytotoxic in the cell viability test and had suitable physicochemical and mechanical properties based on the measurement of zeta potential, water contact angle, mechanical properties, water absorption, thickness change, and gelatin test. To evaluate the anti-adhesion effect, severely injured tendons of rabbits were sutured with the modified Kessler core suture technique and WBPU films were then wrapped around the tendon. Implantation in rabbits showed that the WBPU film had better anti-adhesion effect than PCL films and the untreated control, and demonstrated no significant difference in the anti-adhesion performance from the commercial product Seprafilm based on gross evaluation, histological analysis, and biomechanical assessment. CONCLUSION: Compared to Seprafilm and PCL applied in the tendon anti-adhesion, WBPU had better mechanical properties, low inflammatory reaction, and a proper degradation interval. Dove Medical Press 2018-09-17 /pmc/articles/PMC6149831/ /pubmed/30271142 http://dx.doi.org/10.2147/IJN.S169825 Text en © 2018 Hsu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Hsu, Shan-hui Dai, Lien-Guo Hung, Yu-Min Dai, Niann-Tzyy Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion |
title | Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion |
title_full | Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion |
title_fullStr | Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion |
title_full_unstemmed | Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion |
title_short | Evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion |
title_sort | evaluation and characterization of waterborne biodegradable polyurethane films for the prevention of tendon postoperative adhesion |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149831/ https://www.ncbi.nlm.nih.gov/pubmed/30271142 http://dx.doi.org/10.2147/IJN.S169825 |
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