A novel mechanism for the prevention of transcription replication conflicts

Transcription and replication complexes can coincide in space and time. Such coincidences may result in collisions that trigger genomic instability. The phosphorylation of Mrc1 by different signaling kinases is part of a general mechanism that serves to delay replication in response to different str...

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Detalles Bibliográficos
Autores principales: Canal, Berta, Duch, Alba, Posas, Francesc, de Nadal, Eulàlia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149842/
https://www.ncbi.nlm.nih.gov/pubmed/30250903
http://dx.doi.org/10.1080/23723556.2018.1451233
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author Canal, Berta
Duch, Alba
Posas, Francesc
de Nadal, Eulàlia
author_facet Canal, Berta
Duch, Alba
Posas, Francesc
de Nadal, Eulàlia
author_sort Canal, Berta
collection PubMed
description Transcription and replication complexes can coincide in space and time. Such coincidences may result in collisions that trigger genomic instability. The phosphorylation of Mrc1 by different signaling kinases is part of a general mechanism that serves to delay replication in response to different stresses that trigger a massive transcriptional response in S phase. This mechanism prevents Transcription-Replication Conflicts and maintains genomic integrity in response to unscheduled massive transcription during S phase.
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spelling pubmed-61498422019-03-28 A novel mechanism for the prevention of transcription replication conflicts Canal, Berta Duch, Alba Posas, Francesc de Nadal, Eulàlia Mol Cell Oncol Author's Views Transcription and replication complexes can coincide in space and time. Such coincidences may result in collisions that trigger genomic instability. The phosphorylation of Mrc1 by different signaling kinases is part of a general mechanism that serves to delay replication in response to different stresses that trigger a massive transcriptional response in S phase. This mechanism prevents Transcription-Replication Conflicts and maintains genomic integrity in response to unscheduled massive transcription during S phase. Taylor & Francis 2018-03-28 /pmc/articles/PMC6149842/ /pubmed/30250903 http://dx.doi.org/10.1080/23723556.2018.1451233 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Canal, Berta
Duch, Alba
Posas, Francesc
de Nadal, Eulàlia
A novel mechanism for the prevention of transcription replication conflicts
title A novel mechanism for the prevention of transcription replication conflicts
title_full A novel mechanism for the prevention of transcription replication conflicts
title_fullStr A novel mechanism for the prevention of transcription replication conflicts
title_full_unstemmed A novel mechanism for the prevention of transcription replication conflicts
title_short A novel mechanism for the prevention of transcription replication conflicts
title_sort novel mechanism for the prevention of transcription replication conflicts
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149842/
https://www.ncbi.nlm.nih.gov/pubmed/30250903
http://dx.doi.org/10.1080/23723556.2018.1451233
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