Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition

Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through...

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Detalles Bibliográficos
Autores principales: Popova, Semiramis A., Buczacki, Simon J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149862/
https://www.ncbi.nlm.nih.gov/pubmed/30250932
http://dx.doi.org/10.1080/23723556.2018.1494950
Descripción
Sumario:Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through non-canonical hedgehog signalling effects on the WNT pathway.

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