Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition

Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through...

Descripción completa

Detalles Bibliográficos
Autores principales: Popova, Semiramis A., Buczacki, Simon J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149862/
https://www.ncbi.nlm.nih.gov/pubmed/30250932
http://dx.doi.org/10.1080/23723556.2018.1494950
_version_ 1783356885239332864
author Popova, Semiramis A.
Buczacki, Simon J. A.
author_facet Popova, Semiramis A.
Buczacki, Simon J. A.
author_sort Popova, Semiramis A.
collection PubMed
description Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through non-canonical hedgehog signalling effects on the WNT pathway.
format Online
Article
Text
id pubmed-6149862
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-61498622019-08-07 Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition Popova, Semiramis A. Buczacki, Simon J. A. Mol Cell Oncol Author's Views Cancer cell dormancy is an important source of treatment failure. We studied the molecular characteristics and functional behaviour of dormant colorectal cancer cells finding them to be a differentiated yet plastic population. Organoid drug screening identified itraconazole perturbs dormancy through non-canonical hedgehog signalling effects on the WNT pathway. Taylor & Francis 2018-08-07 /pmc/articles/PMC6149862/ /pubmed/30250932 http://dx.doi.org/10.1080/23723556.2018.1494950 Text en © 2018 The Author(s). Published by Taylor & Francis. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author's Views
Popova, Semiramis A.
Buczacki, Simon J. A.
Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition
title Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition
title_full Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition
title_fullStr Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition
title_full_unstemmed Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition
title_short Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition
title_sort itraconazole perturbs colorectal cancer dormancy through sufu-mediated wnt inhibition
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149862/
https://www.ncbi.nlm.nih.gov/pubmed/30250932
http://dx.doi.org/10.1080/23723556.2018.1494950
work_keys_str_mv AT popovasemiramisa itraconazoleperturbscolorectalcancerdormancythroughsufumediatedwntinhibition
AT buczackisimonja itraconazoleperturbscolorectalcancerdormancythroughsufumediatedwntinhibition

Ejemplares similares